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抹茶绿茶通过抑制 JAK2/STAT3 信号通路预防肥胖诱导的下丘脑炎症。

Matcha green tea prevents obesity-induced hypothalamic inflammation suppressing the JAK2/STAT3 signaling pathway.

机构信息

Tea Research Institute, Zhejiang University, Zijingang Campus, Hangzhou 310058, P. R. China.

出版信息

Food Funct. 2020 Oct 21;11(10):8987-8995. doi: 10.1039/d0fo01500h.

Abstract

Obesity is an increasingly severe global health problem, leading to chronic inflammation and metabolic disorders in both peripheral tissues and the central nervous system. Matcha is a powdered green tea, and it is very popular in recent years as a beverage and food additive. Matcha green tea has been reported to have outstanding potential in regulating obesity-related metabolic syndrome. However, there are few studies on the regulation mechanism of matcha green tea on the central nervous system. In this study, we established a high-fat diet-induced obese mouse model. The results showed that dietary supplementation with matcha could effectively inhibit the weight gain, fat accumulation, glycemia and lipidemia increase, and excessive activation of microglia in the arcuate nucleus of the hypothalamus. Furthermore, we used different concentrations (100%, 80%, 60%, 40%, and 20%, v/v) of ethanol solution to prepare matcha ethanol extracts, and investigated their effects on palmitic acid-induced inflammation of microglial BV-2 cells. The results showed that matcha ethanol extracts could significantly reduce the release of inflammatory cytokines and the expression and phosphorylation of JAK2 and STAT3.

摘要

肥胖是一个日益严重的全球健康问题,可导致外周组织和中枢神经系统发生慢性炎症和代谢紊乱。抹茶是一种粉状绿茶,近年来作为饮料和食品添加剂非常受欢迎。有报道称抹茶绿茶在调节肥胖相关代谢综合征方面具有突出的潜力。然而,关于抹茶绿茶对中枢神经系统的调节机制的研究较少。在本研究中,我们建立了高脂肪饮食诱导的肥胖小鼠模型。结果表明,膳食补充抹茶可有效抑制体重增加、脂肪积累、血糖和血脂升高,以及下丘脑弓状核中小胶质细胞的过度激活。此外,我们使用不同浓度(100%、80%、60%、40%和 20%,v/v)的乙醇溶液制备抹茶乙醇提取物,并研究了它们对棕榈酸诱导的小胶质细胞 BV-2 细胞炎症的影响。结果表明,抹茶乙醇提取物可显著降低炎症细胞因子的释放以及 JAK2 和 STAT3 的表达和磷酸化。

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