College of Horticulture, South China Agricultural University, Guangzhou 510000, China.
Food Funct. 2019 Apr 17;10(4):2061-2074. doi: 10.1039/c8fo02334d.
A high-fat diet results in obesity because of white fat accumulation. Although tea extracts alleviate lipid metabolism disorders and decrease white fat accumulation, the mechanisms underlying the therapeutic actions of different types of Chinese tea are unclear. We established a murine model of obesity by feeding mice with a high-fat diet (HFD) and treating them with atorvastatin (positive control) or water extracts (WEATs) of different tea types. The food and water intake, body weight gain, white fat accumulation, and triglyceride (TG) and total cholesterol (TC) levels were evaluated to assess the effects of the WEATs on obesity. The levels of the lipid metabolism enzymes p-AMPK, CPT-1A and FAS and the pro-inflammatory factors iNOS and IL-6 were determined. The WEATs not only reduced the body weight and white fat accumulation in the HFD-induced obese mice, but also relieved hepatic steatosis. Comparing the effects of the six kinds of tea showed that white tea has the best anti-obesity effect. Yellow tea and raw pu-erh tea significantly up-regulated p-AMPK, green tea, white tea and raw pu-erh tea markedly inhibited FAS, and white tea, yellow tea and oolong tea up-regulated CPT-1. Therefore, it is possible that white tea, yellow tea and oolong tea inhibit obesity by increasing energy expenditure and fatty acid oxidation, while green tea, white tea and raw pu-erh tea exert their effects by inhibiting fatty acid synthesis. In addition, the WEATs also significantly decreased the levels of IL-6, while green tea, yellow tea and oolong tea significantly inhibited iNOS. Different types of tea have specific chemical compositions and can regulate different lipid metabolism related proteins. In conclusion, despite variations in its composition and mechanism of action, tea is a potent anti-obesity agent.
高脂肪饮食会导致肥胖，这是由于白色脂肪的积累。尽管茶提取物可以缓解脂质代谢紊乱并减少白色脂肪的积累，但不同类型的中国茶的治疗作用机制尚不清楚。我们通过给小鼠喂食高脂肪饮食（HFD）并使用阿托伐他汀（阳性对照）或不同茶类的水提取物（WEATs）来建立肥胖小鼠模型。评估食物和水的摄入、体重增加、白色脂肪积累以及甘油三酯（TG）和总胆固醇（TC）水平，以评估 WEATs 对肥胖的影响。测定脂质代谢酶 p-AMPK、CPT-1A 和 FAS 以及促炎因子 iNOS 和 IL-6 的水平。WEATs 不仅减少了 HFD 诱导的肥胖小鼠的体重和白色脂肪积累，还缓解了肝脂肪变性。比较六种茶的效果表明，白茶具有最佳的抗肥胖效果。黄茶和生普洱茶显著上调 p-AMPK，绿茶、白茶和生普洱茶显著抑制 FAS，白茶、黄茶和乌龙茶上调 CPT-1。因此，白茶、黄茶和乌龙茶可能通过增加能量消耗和脂肪酸氧化来抑制肥胖，而绿茶、白茶和生普洱茶则通过抑制脂肪酸合成来发挥作用。此外，WEATs 还显著降低了 IL-6 的水平，而绿茶、黄茶和乌龙茶显著抑制了 iNOS。不同类型的茶具有特定的化学成分，可以调节不同的脂质代谢相关蛋白。总之，尽管茶的组成和作用机制存在差异，但它是一种有效的抗肥胖剂。
