Department of Biochemistry, Federal University of Technology, Akure, Nigeria.
Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.
J Basic Clin Physiol Pharmacol. 2020 Oct 1;32(3):169-177. doi: 10.1515/jbcpp-2019-0360.
This study aimed to explore the protective mechanism of caffeic acid (CAA) and chlorogenic acid (CHA) on cyclosporine (CSA) induced hypertensive rats.
Effect of CAA and CHA on diastolic blood pressure (DBP), mean arterial pressure (MAP), angiotensin-converting enzyme (ACE), e-nucleotide triphosphate dephosphorylase (e-NTPDase), 5' nucleotidase and adenosine deaminase (ADA) activity in CSA-induced hypertensive rats were determined.
CAA and CHA administration stabilized hypertensive effect caused by CSA administration. Also, altered activity of ACE (lung), e-NTPDase, 5' nucleotidase, ADA as well as elevated malondiadehyde (MDA) level was restored in all the treated hypertensive rats in comparison with the untreated hypertensive rats.
Hence, these observed results could underlie some of the mechanisms through which CAA and CHA could offer antihypertensive effect.
本研究旨在探讨咖啡酸（CAA）和绿原酸（CHA）对环孢素（CSA）诱导的高血压大鼠的保护机制。
测定 CAA 和 CHA 对 CSA 诱导的高血压大鼠舒张压（DBP）、平均动脉压（MAP）、血管紧张素转换酶（ACE）、e-核苷酸三磷酸去磷酸酶（e-NTPDase）、5'核苷酸酶和腺苷脱氨酶（ADA）活性的影响。
CAA 和 CHA 给药稳定了 CSA 给药引起的高血压效应。此外，与未治疗的高血压大鼠相比，所有治疗的高血压大鼠的 ACE（肺）、e-NTPDase、5'核苷酸酶、ADA 活性改变以及丙二醛（MDA）水平升高均得到恢复。
因此，这些观察到的结果可以为 CAA 和 CHA 提供抗高血压作用的部分机制提供依据。
