毒蕈碱受体激活后胰腺β细胞中不同葡萄糖掺入钙池的动员。
Mobilization of different pools of glucose-incorporated calcium in pancreatic beta-cells after muscarinic receptor activation.
作者信息
Hellman B, Gylfe E, Bergsten P
出版信息
Adv Exp Med Biol. 1986;211:325-41. doi: 10.1007/978-1-4684-5314-0_30.
PMID:3300191
Abstract
Muscarinic receptor activation resulted in a biphasic mobilization of Ca2+ from isolated pancreatic islets. Glucose was essential for preparing the beta-cells to respond with the initial stimulatory phase. This effect seems to depend on the ability of the sugar to promote active sequestration of Ca2+ in the endoplasmic reticulum.
摘要
毒蕈碱受体激活导致分离的胰岛出现双相性的钙离子动员。葡萄糖对于使β细胞准备好对初始刺激阶段作出反应至关重要。这种效应似乎取决于该糖类促进内质网中钙离子主动隔离的能力。
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