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为艾滋病毒/艾滋病感染者提供住房稳定和病毒抑制的途径:“为多重诊断的艾滋病毒阳性无家可归人群建立医疗之家”倡议的研究结果。

Pathways to housing stability and viral suppression for people living with HIV/AIDS: Findings from the Building a Medical Home for Multiply Diagnosed HIV-positive Homeless Populations initiative.

机构信息

Department of Public Health, Zuckerberg College of Health Sciences, Univeristy of Massachusetts, Lowell, Lowell, MA, United States of America.

Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.

出版信息

PLoS One. 2020 Oct 1;15(10):e0239190. doi: 10.1371/journal.pone.0239190. eCollection 2020.

Abstract

BACKGROUND

People with HIV with co-occurring substance use and mental health diagnoses who are unstably housed have poorer outcomes for retention in care and viral suppression. Navigation models are a potential strategy to help this vulnerable population obtain the necessary medical and non-medical services across multiple service systems. The Health Resources and Services Administration's Special Projects of National Significance: "Building a Medical Home for Multiply-Diagnosed HIV-positive Homeless Populations initiative 2012-2017 found that navigation models may be an effective intervention to support people with HIV with unstable housing improve HIV health outcomes. However, there is limited information about the mechanisms by which this intervention works. In this article, we explore the participant and program factors for achieving stable housing at 6 months and how these factors influence HIV health outcomes.

METHODS AND FINDINGS

This was a prospective study of 471 unstably housed people with HIV enrolled in a navigation intervention across nine sites in the United Stated from 2013-2017. All sites provided HIV primary medical care. Eight sites were located in urban areas and one site served a predominantly rural population. Two sites were federally qualified health centers, three were city or county health departments, one site was a comprehensive HIV/AIDS service organization, and three sites were outpatient or mobile clinics affiliated with a university -based or hospital system. Data were collected via interview and medical chart review at baseline, post 6 and 12 months. Type and dose of navigation activities were collected via a standardized encounter form. We used a path analysis model with housing stability at 6 months as the mediator to examine the direct and indirect effects of participant's socio-demographics and risk factors and navigation on viral suppression and retention in care at 12 months. Housing stability at 6 months was associated with male gender, younger age, viral suppression at baseline, having a lower risk for opiate use, recent homelessness, lower risk of food insecurity, and a longer length of time living with HIV. Participants who increased self-efficacy with obtaining help by 6 months had significantly higher odds of achieving housing stability. Stable housing, fewer unmet needs, moderate to high risk for opiate use, and viral suppression at baseline had a direct effect on viral suppression at 12 months. The intensity of navigation contact had no direct effect on housing stability and a mixed direct effect on viral suppression. Recent diagnosis with HIV, women, greater social support, increased self-efficacy and higher intensity of navigation contact had a direct effect on improved retention in HIV primary care at 12 months.

CONCLUSIONS

In this sample of people with HIV who are experiencing homelessness, housing stability had a significant direct path to viral suppression. Navigation activities did not have a direct effect on the path to housing stability but were directly related to retention in care. These results identify key populations and factors to target resources and policies for addressing the health and social unmet needs of people with HIV to achieve housing stability and HIV health outcomes.

摘要

背景

同时患有物质使用障碍和精神健康问题且居住不稳定的艾滋病毒感染者,其在医疗保健机构中的保留率和病毒抑制率均较差。导航模式是一种潜在的策略,可以帮助这一脆弱群体在多个服务系统中获得必要的医疗和非医疗服务。卫生资源和服务管理局的特别项目具有国家意义:“为多重诊断的艾滋病毒阳性无家可归者建立医疗之家倡议 2012-2017 年发现,导航模式可能是支持居住不稳定的艾滋病毒感染者改善艾滋病毒健康结果的有效干预措施。然而,关于该干预措施的作用机制的信息有限。在本文中,我们探讨了在 6 个月时实现稳定住房的参与者和计划因素,以及这些因素如何影响艾滋病毒健康结果。

方法和发现

这是一项在美国 9 个地点进行的前瞻性研究,共有 471 名居住不稳定的艾滋病毒感染者参与了一项导航干预措施,研究时间为 2013-2017 年。所有地点均提供艾滋病毒初级医疗服务。8 个地点位于城市地区,1 个地点服务于主要农村人口。2 个地点是联邦合格的健康中心,3 个是城市或县卫生部门,1 个是综合艾滋病毒/艾滋病服务组织,3 个是与大学或医院系统相关的门诊或流动诊所。数据通过访谈和医疗记录审查在基线、6 个月和 12 个月时收集。通过标准化的就诊表收集导航活动的类型和剂量。我们使用路径分析模型,以 6 个月时的住房稳定性作为中介,来检验参与者的社会人口统计学和风险因素以及导航对 12 个月时病毒抑制和医疗保健保留率的直接和间接影响。6 个月时的住房稳定性与男性、年轻、基线时病毒抑制、较低的阿片类药物使用风险、最近无家可归、较低的食物不安全风险以及较长的艾滋病毒感染时间有关。6 个月时自我效能感提高以获得帮助的参与者,其获得住房稳定的几率显著增加。6 个月时的稳定住房、较少的未满足需求、中等到高度的阿片类药物使用风险以及基线时的病毒抑制对 12 个月时的病毒抑制有直接影响。导航接触的强度对住房稳定没有直接影响,对病毒抑制有混合的直接影响。最近被诊断出患有艾滋病毒、女性、更大的社会支持、自我效能感的提高以及更高强度的导航接触对 12 个月时改善艾滋病毒初级保健的保留率有直接影响。

结论

在这个经历无家可归的艾滋病毒感染者样本中,住房稳定与病毒抑制有显著的直接关系。导航活动对住房稳定的路径没有直接影响,但与保留在护理中直接相关。这些结果确定了关键人群和因素,以便针对艾滋病毒感染者的健康和社会未满足需求分配资源和政策,以实现住房稳定和艾滋病毒健康结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bae/7529314/e702ce089dbb/pone.0239190.g001.jpg

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