Department of Pathology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Department of Hematology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Diagn Cytopathol. 2021 Apr;49(4):E167-E171. doi: 10.1002/dc.24627. Epub 2020 Oct 1.
Hairy cell leukaemia (HCL) is a rare lymphoproliferative disorder of B cell origin, and uncommonly it affects the lymph node. Fine needle aspiration cytology (FNAC) of lymph node of HCL has rarely been described.
A 41-year-old man presented with pallor, fever, tachycardia, generalized lymphadenopathy, and massive splenomegaly. The FNAC of the cervical lymph node was done. The smears showed many atypical lymphocytes with a plasmacytoid appearance. There were many large cells with round to reniform shaped nuclei having with hair-like cytoplasmic processes. Flow cytometry (FCM) revealed a clonal B cell population with light chain restriction and positive CD20, CD79b, CD22, CD11c, CD25, CD103, CD123, and CD200 markers.
The characteristic cytological features such as atypical lymphoid cells, large cells with hairy projections along with FCM findings, are helpful in the diagnosis of HCL.
毛细胞白血病（HCL）是一种罕见的 B 细胞来源的淋巴增生性疾病，它很少累及淋巴结。HCL 的淋巴结细针抽吸细胞学（FNAC）很少被描述。
一名 41 岁男性出现苍白、发热、心动过速、全身淋巴结病和巨大脾肿大。进行了颈部淋巴结的 FNAC。涂片显示许多具有浆细胞样外观的异型淋巴细胞。有许多大细胞，具有圆形到腰果形核，具有毛发状细胞质突起。流式细胞术（FCM）显示克隆 B 细胞群，具有轻链限制和阳性 CD20、CD79b、CD22、CD11c、CD25、CD103、CD123 和 CD200 标志物。
特征性的细胞学特征，如异型淋巴细胞、具有毛发状突起的大细胞，以及 FCM 发现，有助于 HCL 的诊断。
