Department of Surgery, Erasmus MC, University Medical Center, Rotterdam, the Netherlands; Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
Department of Surgery, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Transplant Rev (Orlando). 2020 Oct;34(4):100571. doi: 10.1016/j.trre.2020.100571. Epub 2020 Sep 17.
The impact of donor body mass index (BMI) on graft function outcomes in liver transplantation (LT) is still controversial. The aim of this study was to review the current evidence investigating the effect of donor BMI on outcomes in patients undergoing LT. A systematic review was performed to evaluate relevant outcomes such as the availability of data on donor BMI as well as graft and patient survival after LT. Screening of 901 articles resulted in 11 observational studies for data extraction. In adult deceased donor after brain death and living donor LT, donor BMI was not associated with graft and patient survival. However, high donor BMI was associated with a higher chance of macrosteatosis besides a significantly higher incidence of declined livers. In pediatric LT, severe obesity in adult donors with BMI ≥35 was associated with graft loss and mortality, whereas obesity in pediatric donors was not associated with graft loss and mortality. Accordingly, donor BMI is not associated with long-term outcomes in adult patients undergoing LT. However, further research should be conducted to identify the effect of donor BMI on outcomes in LT.
供体体重指数（BMI）对肝移植（LT）中移植物功能结果的影响仍存在争议。本研究旨在回顾目前关于供体 BMI 对 LT 患者结局影响的证据。进行了系统评价，以评估相关结局，例如供体 BMI 数据的可用性以及 LT 后移植物和患者的存活率。对 901 篇文章进行筛选后，有 11 项观察性研究进行了数据提取。在脑死亡后成年已故供体和活体供体 LT 中，供体 BMI 与移植物和患者存活率无关。然而，高供体 BMI 与大脂肪变性的几率增加有关，此外，功能下降的肝脏发生率也显著增加。在儿科 LT 中，BMI≥35 的成年供体严重肥胖与移植物丢失和死亡率相关，而儿科供体的肥胖与移植物丢失和死亡率无关。因此，供体 BMI 与接受 LT 的成年患者的长期结局无关。然而，应进一步研究以确定供体 BMI 对 LT 结局的影响。
