School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, People's Republic of China.
School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, People's Republic of China.
Nanotechnology. 2021 Jan 15;32(3):035102. doi: 10.1088/1361-6528/abbd71.
The efficiency of producing hydroxyl radicals (·OH) from hydrogen peroxide (HO) catalyzed by different iron compounds have been explored extensively. Exclusively, ferrocenecarboxylic acid (FCA) showed the best catalyzed activity for ·OH generation. Then, we designed and prepared near-infrared (NIR) light-responsive and folate-targeted nanoplatform, which co-delivered FCA, cisplatin and indocyanine green (ICG) for improving antitumor therapy through amplified oxidative stress. The noteworthy observation is that under the irradiation of NIR light, the lecithin structure could able to depolymerize through the photothermal conversion mechanism of encapsulated dye ICG, which has achieved an intelligent release of drugs. In addition, the released cisplatin is not only fully effective to damage the DNA of cancer cells but it is able to induce the production of intracellular HO, which could further be catalyzed by FCA to generate toxic ·OH for oxidative damage via Fenton and Haber-Weiss reaction. This original strategy may provide an efficient way for improved chemotherapy via amplified oxidative stress.
人们广泛探索了不同铁化合物催化过氧化氢（HO）产生羟基自由基（·OH）的效率。特别地，二茂铁羧酸（FCA）表现出最佳的·OH 生成催化活性。随后，我们设计并制备了近红外（NIR）光响应和叶酸靶向的纳米平台，共同递送 FCA、顺铂和吲哚菁绿（ICG），通过放大氧化应激来改善肿瘤治疗。值得注意的是，在近红外光的照射下，通过封装染料 ICG 的光热转换机制，卵磷脂结构能够解聚，从而实现药物的智能释放。此外，释放的顺铂不仅能有效地破坏癌细胞的 DNA，还能诱导细胞内 HO 的产生，HO 可以进一步被 FCA 催化，通过 Fenton 和 Haber-Weiss 反应生成有毒的·OH 进行氧化损伤。这种新颖的策略可能为通过放大氧化应激改善化疗提供一种有效的方法。
