From the Departments of Anesthesiology and Perioperative Medicine.
Health Science Research, Mayo Clinic, Jacksonville, Florida.
Anesth Analg. 2021 May 1;132(5):1421-1428. doi: 10.1213/ANE.0000000000005213.
Subjective evaluations to confirm recovery from neuromuscular blockade with a peripheral nerve stimulator (PNS) is inadequate. Quantitative monitors are the only reliable method to confirm adequate recovery of neuromuscular function. Unfortunately, many clinicians are unfamiliar with such devices and there is concern that the introduction of objective monitoring would be exceedingly laborious and could cause workflow delays. This study investigates how long it takes experienced nurse anesthetists to apply various neuromuscular devices as well as their perception regarding the ease of application.
Twenty nurse anesthetists were consented and participated in an educational session that familiarized them with 3 devices: SunStim Plus PNS (SunMed, Grand Rapids, MI), the acceleromyography-based IntelliVue NMT device (Philips, Amsterdam, the Netherlands), and electromyography-based TetraGraph device (Senzime B.V., Uppsala, Sweden). Participants were timed while placing each monitor on patients in a real-world setting. For the quantitative devices (IntelliVue NMT and TetraGraph), participants were also timed when obtaining calibrated baseline train-of-four (TOF) ratios. Friedman test and pairwise Wilcoxon signed-rank tests were used to evaluate the difference in time to connect different devices. Participants were surveyed about how easy they found it to utilize these devices.
After adjusting for multiple comparison, time to connect was significantly less for PNS (median, 29; range, 16-58 seconds) compared to either the TetraGraph device (median, 62.8; range, 32-101 seconds; P < .001) or the IntelliVue NMT device (median, 46; range: 28-90 seconds; P < .001). The difference in time to connect between the TetraGraph device and the IntelliVue NMT device was not statistically significant (P = .053), but it took significantly less time to calibrate the TetraGraph device than the IntelliVue NMT device (median difference, -16; range, -88 to 49 seconds; P = .002). The participants found applying either the IntelliVue NMT device (P = .042) or the TetraGraph device (P = .048) more difficult than applying a PNS while finding it easier to calibrate the TetraGraph device versus the IntelliVue NMT device (P < .001).
It takes 19 seconds longer to apply a quantitative neuromuscular monitor (the IntelliVue NMT device) than a PNS. While this difference reached significance, this relatively minimal additional time represents an inappropriate barrier to the application of quantitative monitors. Regardless of which quantitative monitor was utilized, these nurse anesthetists found the application and utilization of such devices relatively straightforward.
使用外周神经刺激器(PNS)主观评估确认神经肌肉阻滞恢复情况并不充分。定量监测器是确认神经肌肉功能充分恢复的唯一可靠方法。不幸的是,许多临床医生不熟悉这些设备,并且担心引入客观监测会非常繁琐,并且可能导致工作流程延迟。本研究调查了经验丰富的麻醉护士应用各种神经肌肉设备所需的时间,以及他们对应用便利性的看法。
征得 20 名麻醉护士的同意,并让他们参加一个教育课程,使他们熟悉 3 种设备:SunStim Plus PNS(SunMed,大急流城,MI),基于加速度计的 IntelliVue NMT 设备(飞利浦,阿姆斯特丹,荷兰)和基于肌电图的 TetraGraph 设备(Senzime B.V.,乌普萨拉,瑞典)。参与者在真实环境中将每个监视器放置在患者身上时,会被计时。对于定量设备(IntelliVue NMT 和 TetraGraph),参与者还会在获得校准的强直刺激 4 次(TOF)比值时计时。使用 Friedman 检验和成对 Wilcoxon 符号秩检验评估连接不同设备的时间差异。参与者被调查他们认为使用这些设备的难易程度。
调整多次比较后,与 TetraGraph 设备(中位数,62.8;范围,32-101 秒;P <.001)或 IntelliVue NMT 设备(中位数,46;范围:28-90 秒;P <.001)相比,PNS 连接时间明显更短(中位数,29;范围,16-58 秒)。TetraGraph 设备与 IntelliVue NMT 设备之间连接时间的差异没有统计学意义(P =.053),但 TetraGraph 设备的校准时间明显短于 IntelliVue NMT 设备(中位数差异,-16;范围,-88 至 49 秒;P =.002)。参与者发现应用 IntelliVue NMT 设备(P =.042)或 TetraGraph 设备(P =.048)比应用 PNS 更困难,而发现更容易校准 TetraGraph 设备比 IntelliVue NMT 设备(P <.001)。
应用定量神经肌肉监测器(IntelliVue NMT 设备)比 PNS 多花费 19 秒。尽管这种差异具有统计学意义,但这种相对较小的额外时间代表了应用定量监测器的不适当障碍。无论使用哪种定量监测器,这些麻醉护士都发现应用和使用这些设备相对简单。