Ramirez-Ronda C, Colon M, Saavedra S, Sabbaj J, Corrado M L
Am J Med. 1987 Jun 26;82(6B):75-8. doi: 10.1016/0002-9343(87)90623-1.
Twenty-five patients with urinary tract infection were treated with norfloxacin, a fluoroquinolone antibacterial with a wide spectrum of activity for an oral agent. Of 22 patients who were evaluable, 20 had complicated urinary tract infection; infection was cured in 19 patients at one week after treatment. Optimal alternative treatments were also selected in norfloxacin's stead, based on each patient's characteristics and the results of susceptibility testing for each isolated pathogen. Direct costs for alternative treatment ranged from $7 to $970. The results indicated that for those patients with suspected or proven urinary tract infection caused by multiresistant bacteria, therapy with norfloxacin may represent a cost-effective choice.
25例尿路感染患者接受了诺氟沙星治疗，诺氟沙星是一种口服的具有广泛抗菌活性的氟喹诺酮类抗菌药物。在22例可评估的患者中，20例患有复杂性尿路感染；治疗1周后，19例患者的感染得到治愈。还根据每位患者的特征和每种分离病原体的药敏试验结果，选择了诺氟沙星的最佳替代治疗方案。替代治疗的直接费用从7美元到970美元不等。结果表明，对于那些由多重耐药菌引起的疑似或确诊尿路感染患者，使用诺氟沙星治疗可能是一种具有成本效益的选择。
