Kim Jong-Ho, Lim Man-Sup, Lee Sang-Hwa, Kwon Young-Suk, Lee Jae Jun, Sohn Jong-Hee
Department of Anesthesiology and Pain Medicine, Chuncheon Sacred Heart Hospital, Hallym University college of Medicine, Chuncheon 24253, Korea.
Institute of New Frontier Research, College of Medicine, Hallym University, Chuncheon 24253, Korea.
J Clin Med. 2020 Sep 29;9(10):3154. doi: 10.3390/jcm9103154.
The impact of migraine on postoperative nausea and vomiting (PONV) is controversial, and few studies have focused on their relationship. Thus, we investigated the impact of migraine, among other risk factors, on PONV in a large retrospective study. We analyzed 10 years of clinical data from the Smart Clinical Data Warehouse of Hallym University Medical Center. PONV was defined as nausea or vomiting within the first 24 h after surgery. Patients diagnosed by a neurologist and with a history of triptan use before surgery were enrolled into the migraine group. We enrolled 208,029 patients aged > 18 years who underwent general anesthesia (GA), among whom 19,786 developed PONV within 24 h after GA and 1982 had migraine. Before propensity score matching, the unadjusted and fully adjusted odds ratios (ORs) for PONV in subjects with versus without migraine were 1.52 (95% confidence interval (CI), 1.34-1.72; < 0.001) and 1.37 (95% CI, 1.21-1.56; < 0.001), respectively. The OR for PONV in patients with migraine was also high (OR, 1.37; 95% CI, 1.13-1.66; = 0.001) after matching. Our findings suggest that migraine is a significant risk factor for PONV.
偏头痛对术后恶心呕吐（PONV）的影响存在争议，很少有研究关注它们之间的关系。因此，在一项大型回顾性研究中，我们调查了偏头痛以及其他风险因素对PONV的影响。我们分析了翰林大学医学中心智能临床数据仓库10年的临床数据。PONV定义为术后24小时内出现恶心或呕吐。由神经科医生诊断且术前有使用曲坦类药物史的患者被纳入偏头痛组。我们纳入了208,029例年龄>18岁接受全身麻醉（GA）的患者，其中19,786例在GA后24小时内发生PONV，1982例有偏头痛。在倾向评分匹配前，有偏头痛与无偏头痛受试者PONV的未调整和完全调整优势比（OR）分别为1.52（95%置信区间（CI），1.34 - 1.72；P<0.001）和1.37（95%CI，1.21 - 1.56；P<0.001）。匹配后，偏头痛患者PONV的OR也较高（OR，1.37；95%CI，1.13 - 1.66；P = 0.001）。我们的研究结果表明，偏头痛是PONV的一个重要风险因素。
