与空腹血清胰岛素和尿白蛋白排泄相关的非酒精性脂肪性肝病标志物，独立于空腹血糖。
Non-Alcoholic Fatty Liver Disease Markers Associated with Fasting Serum Insulin and Urinary Albumin Excretion Independent of Fasting Plasma Glucose.
作者信息
Katoh Shuichi, Peltonen Markku, Zeniya Mikio, Sakamoto Yoichi, Utsunomiya Kazunori, Nishimura Rimei, Tuomilehto Jaakko
机构信息
Division of Diabetes, Metabolism & Endocrinology, The Jikei University School of Medicine, 3-25-8 Nishishimbashi, Minato-ku, Tokyo 105-8461, Japan.
Public Health Promotion Unit, Finnish Institute for Health and Welfare, Mannerheimintie 166, FI-00271 Helsinki, Finland.
出版信息
J Clin Med. 2020 Sep 29;9(10):3161. doi: 10.3390/jcm9103161.
OBJECTIVE
We examined the association between non-alcoholic fatty liver disease (NAFLD) markers and fasting serum immunoreactive insulin (FIRI) and urinary albumin excretion (UAE).
SUBJECTS AND METHODS
This study comprised Periods I and II from January 2007 to May 2009, and from June 2009 to December 2011, respectively. After excluding people with ethanol intake ≥210 g/week in men and ≥140 g/week in women, 961 people (613 men, 348 women; mean age: 44 years) were included. We evaluated the fatty liver using ultrasonography score (FLUS) and measured liver enzymes.
RESULTS
The mean observation period was 25 ± 9 months. We stratified people into two groups by fasting plasma glucose (FPG) in Period I. The cutoff point between the lower FPG and higher FPG was 100 mg/dL. In regression analysis, serum alanine aminotransferase (ALT) ( < 0.001), FLUS ( < 0.001) and γ-glutamyl transpeptidase (GGTP) ( = 0.022) in Period I were independently associated with FIRI in Period II, whereas in all participants FPG was not. ALT ( < 0.001) and GGTP ( = 0.001) were also independently associated with UAE in people with FPG < 100 mg/dL in Period II.
CONCLUSIONS
Some NAFLD markers were associated with FIRI and UAE independently of fasting plasma glucose.
目的
我们研究了非酒精性脂肪性肝病（NAFLD）标志物与空腹血清免疫反应性胰岛素（FIRI）及尿白蛋白排泄率（UAE）之间的关联。
研究对象与方法
本研究分别包括2007年1月至2009年5月的第一阶段以及2009年6月至2011年12月的第二阶段。排除男性乙醇摄入量≥210克/周且女性≥140克/周的人群后，纳入了961人（男性613人，女性348人；平均年龄：44岁）。我们使用超声评分（FLUS）评估脂肪肝情况并检测肝酶。
结果
平均观察期为25±9个月。在第一阶段，我们根据空腹血糖（FPG）将人群分为两组。较低FPG与较高FPG的分界点为100毫克/分升。在回归分析中，第一阶段的血清丙氨酸氨基转移酶（ALT）（<0.001）、FLUS（<0.001）和γ-谷氨酰转肽酶（GGTP）（=0.022）与第二阶段的FIRI独立相关，而在所有参与者中FPG并非如此。在第二阶段FPG<100毫克/分升的人群中，ALT（<0.001）和GGTP（=0.001）也与UAE独立相关。
结论
一些NAFLD标志物与FIRI和UAE独立相关，与空腹血糖无关。
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