Whiteley H E, Everitt J I, Kakoma I, James M A, Ristic M
Am J Trop Med Hyg. 1987 Jul;37(1):1-8. doi: 10.4269/ajtmh.1987.37.1.
Fatal cases of experimental Plasmodium falciparum (Indochina I) in Bolivian squirrel monkeys (Saimiri sciureus boliviensis) were examined by histologic and ultrastructural methods. Gross lesions were characterized by hepatosplenomegaly and interstitial pulmonary changes. Histologically, there was marked diffuse reticuloendothelial hyperplasia, pulmonary alveolar septal thickening, mesangioproliferative glomerulonephropathy, sequestration of parasitized erythrocytes in deep vascular beds, degenerative parenchymal changes in the liver and myocardium, and in one case retinal and cerebral hemorrhage. These data indicate that the Bolivian squirrel monkey is a good model for studying pathologic changes associated with human falciparum malaria.
通过组织学和超微结构方法对玻利维亚松鼠猴（Saimiri sciureus boliviensis）中实验性恶性疟原虫（印支I型）致死病例进行了检查。大体病变的特征为肝脾肿大和间质性肺改变。组织学上，有明显的弥漫性网状内皮细胞增生、肺泡间隔增厚、系膜增生性肾小球肾炎、深部血管床中被寄生红细胞的滞留、肝脏和心肌实质的退行性改变，以及1例视网膜和脑出血。这些数据表明，玻利维亚松鼠猴是研究与人类恶性疟疾相关病理变化的良好模型。
