Division of Metabolism, Ospedale Pediatrico Bambino Gesù, IRCSS, piazza S. Onofrio 4, 00165, Rome, Italy.
Hospital Pharmacy, Ospedale Pediatrico Bambino Gesù, IRCSS, Rome, Italy.
Orphanet J Rare Dis. 2020 Oct 1;15(1):274. doi: 10.1186/s13023-020-01552-z.
Patients with hereditary fructose intolerance need to follow a life-long fructose dietary and drug restriction to prevent symptoms of intoxication. Concerns about vaccines administration have been manifested overtime, for the risk of a life-threatening acute intoxication. For this reason, at Ospedale Pediatrico Bambino Gesù we performed a deepen research from open sources, datasheets and Pharmaceutical Companies informations from the most common Italian and European vaccines, which are carried out in infancy and childhood. As a safe threshold of 2.4 mg/kg/dose was recently established for oral and parenteral (other than i.v.) route, the manuscript clarifies the safe administration of majority of vaccines in patients with hereditary fructose intolerance.
遗传性果糖不耐受患者需要终生遵循果糖饮食和药物限制，以预防中毒症状。随着时间的推移，人们对疫苗接种的担忧已经显现出来，因为这有危及生命的急性中毒的风险。出于这个原因，在 Ospedale Pediatrico Bambino Gesù，我们从公开来源、数据表和意大利及欧洲常见疫苗的制药公司信息中进行了深入研究，这些疫苗在婴儿期和儿童期使用。由于最近为口服和肠外（非静脉内）途径建立了 2.4mg/kg/剂量的安全阈值，因此本文阐明了遗传性果糖不耐受患者中大多数疫苗的安全给药。
