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空气污染与癌症的全过程:拓展我们对环境暴露与癌症之间关系的理解。

Air Pollution across the Cancer Continuum: Extending Our Understanding of the Relationship between Environmental Exposures and Cancer.

机构信息

Huntsman Cancer Institute, Cancer Control and Population Sciences, University of Utah School of Medicine, Salt Lake City, Utah.

Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah.

出版信息

Cancer Epidemiol Biomarkers Prev. 2020 Oct;29(10):1876-1879. doi: 10.1158/1055-9965.EPI-19-1588.

Abstract

Previous studies of the environment and cancer have focused on etiology, showing that extrinsic factors in the environment contribute to 70% to 90% of cancers. Cancer patients and survivors often continue to live in the same neighborhoods they resided in before their cancer diagnosis. Thus, patients and survivors are exposed to the same environmental contexts that likely contributed to their original cancer, but little is known about the health effects of continued exposure to carcinogens after a cancer diagnosis. This commentary provides a summary of studies of the association between PM and cancer mortality among patients and PM and posttreatment morbidity among cancer survivors, and proposes new directions and opportunities for future research on such topics.

摘要

先前有关环境与癌症的研究主要集中在病因学上,表明环境中的外在因素导致了 70% 至 90%的癌症。癌症患者和幸存者通常仍然居住在癌症诊断前居住的同一社区。因此,患者和幸存者暴露于可能导致其最初癌症的相同环境中,但对于癌症诊断后持续接触致癌物的健康影响知之甚少。本评论总结了 PM 与癌症患者死亡率之间的关联研究,以及 PM 与癌症幸存者治疗后发病率之间的关联研究,并为今后此类主题的研究提出了新的方向和机会。

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