Heymann M A
Am Rev Respir Dis. 1987 Jul;136(1):222-4. doi: 10.1164/ajrccm/136.1.222.
The action and interaction of many products of arachidonic acid metabolism can affect the pulmonary circulation in the perinatal period. The rapid increase in pulmonary blood flow with the onset of ventilation likely is brought about to a large degree by the production locally of prostaglandin I2 (PGI2). This can be stimulated by purely mechanical factors, by the normally increasing concentrations of angiotension II, by the 02-mediated release of bradykinin, or perhaps by other phenomena. Prostaglandin D2 release from mast cells also may play some role. The opposing pulmonary vascular effect, i.e., pulmonary vasoconstriction, of leukotrienes is likely to play a role in regulating fetal pulmonary blood flow. Inhibition of the production or action of these substances will allow for vasodilatation, and it is probable that perinatal pulmonary vascular tone reflects a balance between local prostaglandin and leukotriene production.
花生四烯酸代谢的许多产物的作用及相互作用会影响围产期的肺循环。随着通气开始，肺血流量迅速增加，这在很大程度上可能是由局部产生的前列腺素I2（PGI2）所致。这可受到单纯机械因素、血管紧张素II浓度正常升高、缓激肽的02介导释放或者其他现象的刺激。肥大细胞释放的前列腺素D2也可能起一定作用。白三烯的相反肺血管效应，即肺血管收缩，可能在调节胎儿肺血流量中起作用。抑制这些物质的产生或作用将导致血管舒张，围产期肺血管张力很可能反映了局部前列腺素和白三烯产生之间的平衡。
