Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA.
Genes Dev. 2020 Oct 1;34(19-20):1287-1303. doi: 10.1101/gad.341156.120.
There are many large protein complexes involved in transcription in a chromatin context. However, recent studies on the SAGA coactivator complex are generating new paradigms for how the components of these complexes function, both independently and in concert. This review highlights the initial discovery of the canonical SAGA complex 23 years ago, our evolving understanding of its modular structure and the relevance of its modular nature for its coactivator function in gene regulation.
在染色质环境中，有许多涉及转录的大型蛋白质复合物。然而，最近关于 SAGA 共激活因子复合物的研究正在为这些复合物的组成部分如何独立和协同发挥作用提供新的范例。本文回顾了 23 年前对经典 SAGA 复合物的最初发现，以及我们对其模块化结构及其模块化性质对其在基因调控中的共激活因子功能的相关性的不断发展的理解。
