Potyl'chanskaia O L, Araviĭskiĭ R A
Antibiot Med Biotekhnol. 1987 May;32(5):357-60.
The combined effect of various polyenic antibiotics and other antifungal and antibacterial drugs on Candida was studied. The efficacy of the combinations was estimated with the method of square titration followed by quantitative plating out of the samples. By the interaction type the combinations were divided into 3 groups. The character of the drug interaction in these groups might be considered as indifferent, additive or synergistic. No antagonistic effect was observed in any of the combinations. The findings may be useful in more successful treatment of candidiasis when monotherapy is not sufficiently efficient, as well as in optimization of schemes for treating mixed infections.
研究了多种多烯类抗生素与其他抗真菌和抗菌药物对念珠菌的联合作用。采用方阵滴定法，随后对样品进行定量平板接种，评估联合用药的疗效。根据相互作用类型，将联合用药分为3组。这些组中药物相互作用的特征可视为无关、相加或协同。在任何联合用药中均未观察到拮抗作用。这些发现对于在单一疗法效果不佳时更成功地治疗念珠菌病以及优化混合感染的治疗方案可能有用。
