Farooque Umar, Cheema Asfand Yar, Kumar Ranjeet, Saini Gagandeep, Kataria Saurabh
Neurology, Dow University of Health Sciences, Karachi, PAK.
Medicine, Lahore Medical and Dental College, Lahore, PAK.
Cureus. 2020 Aug 29;12(8):e10112. doi: 10.7759/cureus.10112.
Periodic paralyses are a group of disorders characterized by episodes of muscle paralyses. They are mainly divided as primary (hereditary) and secondary (acquired) periodic paralyses. Primary periodic paralyses occur as a result of mutations in genes encoding subunits of muscle membrane channel proteins such as sodium, calcium, and potassium channels, resulting in impairment of their properties. Primary periodic paralyses are further classified on the basis of affected ion channels and other associated complications. Some of these periodic paralyses are hyperkalemic periodic paralysis (Na-channel mutation), hypokalemic periodic paralysis (Na- or Ca-channel mutation), Andersen's syndrome (K-channel mutation), etc.
周期性麻痹是一组以肌肉麻痹发作为特征的疾病。它们主要分为原发性（遗传性）和继发性（后天性）周期性麻痹。原发性周期性麻痹是由于编码肌肉膜通道蛋白亚基的基因突变所致，如钠、钙和钾通道，导致其特性受损。原发性周期性麻痹根据受影响的离子通道和其他相关并发症进一步分类。其中一些周期性麻痹包括高钾性周期性麻痹（钠通道突变）、低钾性周期性麻痹（钠或钙通道突变）、安德森综合征（钾通道突变）等。
