Microbiology Research Department, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, CDMX 14080, Mexico.
Pediatric Pulmonology Clinical Ward, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, CDMX 14080, Mexico.
J Immunol Res. 2020 Sep 14;2020:8235149. doi: 10.1155/2020/8235149. eCollection 2020.
Childhood tuberculosis (TB) is a significant public health problem and the ninth leading cause of death worldwide. Progression of infection to active disease depends on mycobacterial virulence, environmental diversity, and host susceptibility and immune response. In children, malnutrition and immaturity of the immune system contribute to an inadequate immune response. Coinfections, though rarely described in TB, might be associated with host immune deficiencies. Here, we describe the immunological evaluation of eight pediatric patients infected with a member of the complex, most of them with concomitant pulmonary infections (bacteria, viruses, or fungi). We assessed the functionality of several innate immunity receptors, IL-12 receptor, and IFN- receptor, as well as the antioxidant levels (glutathione), which are essential mechanisms for fighting intracellular pathogens such as . . This study is aimed at developing a thorough immunological evaluation of patients with TB and a coinfection.
儿童结核病（TB）是一个重大的公共卫生问题，也是全球第九大死亡原因。感染进展为活动性疾病取决于分枝杆菌的毒力、环境多样性以及宿主的易感性和免疫反应。在儿童中，营养不良和免疫系统不成熟导致免疫反应不足。合并感染在结核病中很少见，但可能与宿主免疫缺陷有关。在这里，我们描述了对感染复合体成员的 8 名儿科患者的免疫学评估，其中大多数患者伴有肺部合并感染（细菌、病毒或真菌）。我们评估了几种先天免疫受体、IL-12 受体和 IFN-受体的功能，以及抗氧化剂水平（谷胱甘肽），这些都是对抗如 等细胞内病原体的重要机制。本研究旨在对结核病和合并感染患者进行全面的免疫学评估。
