Navid Sepehr, Sadegh-Ehdaei Bahar, Shabani Mehdi, Hasani Melika, Mirzaei Arezoo, Ghazvini Kiarash, Youssefi Masoud, Keikha Masoud
Department of Microbiology, School of Medicine, Isfahan Medical University, Isfahan, Iran.
M.Sc. of Molecular Genetics, Sana Institue of Higher Education, Sari, Iran.
Access Microbiol. 2020 Feb 17;2(4):acmi000106. doi: 10.1099/acmi.0.000106. eCollection 2020.
is among the opportunist pathogens of atypical mycobacteria emergence (atypical mycobacteria) that is one of the isolated and reported environmental and clinical specimens. Numerous cases of osteo-articular infections of this bacterium are reported nowadays, while the pulmonary infection is rare. We identified in non-healing wound infection of an elderly woman with history of diabetes mellitus. She has negative tests for HIV, HBV and HCV, but was positive for HTLV-1. The patient was referred according to mild-fever, non-healing, destructive, and swelled lesion on her left foot. The mycobacterial wounds infection was suspected due to her non-conclusive previous treatment. The pathology, acid-fast staining, conventional and 16S rRNA sequencing confirmed the micro-organism to be . Finally, the patient recovered following two-week consumption of clarithromycin, ethambutol and rifabutin. The results of this study provide evidence on the potential pathogenicity, clinical outcomes and treatment of infections caused by this bacterium.
是非典型分枝杆菌(非典型分枝杆菌)这一机会致病菌中的一种,是从环境和临床标本中分离并报告的。如今有许多该细菌引起骨关节炎感染的病例报道,而肺部感染较为罕见。我们在一名有糖尿病史的老年女性的不愈合伤口感染中发现了它。她的HIV、HBV和HCV检测均为阴性,但HTLV - 1检测呈阳性。该患者因左脚有低热、不愈合、破坏性且肿胀的病变而前来就诊。由于其先前治疗效果不明确,怀疑是分枝杆菌伤口感染。病理检查、抗酸染色、常规和16S rRNA测序证实该微生物为 。最后,患者在服用克拉霉素、乙胺丁醇和利福布汀两周后康复。本研究结果为该细菌引起感染的潜在致病性、临床结局及治疗提供了证据。