Zhmareva E N, Brodskaia I A, Berezin V A, Shevchenko G M
Arkh Patol. 1987;49(4):87-91.
Data on the application of neurospecific proteins S-100, GFAP, D2 glycoprotein and neuron-specific enolase (NSE) in the differential tumor diagnosis are reviewed. S-100 protein and GFAP are found in well differentiated astroglial tumors. S-100 protein can be used as melanoma and Schwannoma specific marker. In malignant CNS tumors there is a decrease of S-100 protein content up to its complete disappearance, while the content of GFAP is variable. D2 glycoprotein is detected in gliomas and medulloblastomas, being absent in other brain tumors. NSE is invariably present in apudomas and was also found in the majority of investigated astrocytomas, ependymomas, glioblastomas and in some medulloblastomas.
综述了神经特异性蛋白S-100、胶质纤维酸性蛋白（GFAP）、D2糖蛋白和神经元特异性烯醇化酶（NSE）在肿瘤鉴别诊断中的应用数据。在高分化星形胶质细胞瘤中可发现S-100蛋白和GFAP。S-100蛋白可用作黑色素瘤和神经鞘瘤的特异性标志物。在恶性中枢神经系统肿瘤中，S-100蛋白含量降低直至完全消失，而GFAP的含量则有所不同。在胶质瘤和髓母细胞瘤中可检测到D2糖蛋白，而在其他脑肿瘤中则不存在。NSE始终存在于APUD瘤中，并且在大多数研究的星形细胞瘤、室管膜瘤、胶质母细胞瘤和一些髓母细胞瘤中也有发现。
