Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.
Head and Neck Surgery & Forensic Dissection Research center (HNS&FDRc), Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.
Laryngoscope. 2021 Apr;131(4):E1198-E1208. doi: 10.1002/lary.29107. Epub 2020 Oct 2.
Squamous cell carcinoma of nasal vestibule and pyramid is rare, thus classification, treatment protocol, and indications for elective neck treatment are still controversial. Nasal reconstruction is challenging, as well, and prosthesis is still used.
Retrospective cohort study.
Retrospective review of patients surgically treated from 2010 to 2018 in a single Institution. Advanced tumors were further treated with adjuvant irradiation. Reconstruction strategy included grafts, locoregional and free flaps, and was customized on layers removed.
Forty-five patients were enrolled. The 5-year overall survival and disease-free survival were 81.9% ± 7.45% and 61.9% ± 9.09%, respectively. Wang's classification, site of origin, extent of surgery and margins status significantly correlated with prognosis and recurrence rate. Regional recurrences occurred in patients affected by advanced tumors who did not receive any form of elective neck treatment.
Multidisciplinary management and a proper reconstructive algorithm are recommended. Adjuvant irradiation and elective neck treatment should be advocated for advanced stage high-risk patients.
鼻腔前庭和锥体的鳞状细胞癌较为罕见，因此分类、治疗方案和选择性颈部治疗的适应证仍存在争议。鼻重建也具有挑战性，目前仍使用假体。
回顾性队列研究。
回顾性分析了 2010 年至 2018 年在一家机构接受手术治疗的患者。对晚期肿瘤进一步采用辅助放疗。重建策略包括移植物、局部和游离皮瓣，并根据切除的层次进行定制。
共纳入 45 例患者。5 年总生存率和无病生存率分别为 81.9%±7.45%和 61.9%±9.09%。Wang 分类、起源部位、手术范围和切缘状态与预后和复发率显著相关。局部复发发生在未接受任何形式选择性颈部治疗的晚期肿瘤患者中。
建议采用多学科管理和适当的重建算法。对于高危晚期患者，应提倡辅助放疗和选择性颈部治疗。
4.喉镜，131：E1198-E1208，2021。
