Scheurleer Willem Frederik Julius, Tagliaferri Luca, Rijken Johannes A, Crescio Claudia, Rizzo Davide, Mattiucci Gian Carlo, Pameijer Frank A, de Bree Remco, Fionda Bruno, de Ridder Mischa, Bussu Francesco
Department of Head and Neck Surgical Oncology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
UOC Radioterapia Oncologica, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario ''A. Gemelli'' IRCCS, Largo Agostino Gemelli, 8, 00168 Rome, Italy.
Cancers (Basel). 2023 Jun 1;15(11):3028. doi: 10.3390/cancers15113028.
Squamous cell carcinoma of the nasal vestibule is reported to account for less than one percent of all head and neck malignancies. It lacks a designated WHO ICD-O topography code, and multiple systems are available for the staging of this disease, which results in unwanted variability and the subsequent poor reliability of data. The aim of this study was to evaluate the currently available staging systems for cancer of the nasal vestibule, including the recently introduced classification by Bussu et al., which built on Wang's original concept but with clearer anatomical cutoffs. Different staging systems for cancer of the nasal vestibule (UICC nasal cavity, UICC skin cancer of the head and neck, Wang and Bussu et al.) were evaluated via a retrospective analysis of 148 patients. The staging system, per Bussu et al., had the most balanced allocation of patients among the stages. When using the Wang classification as a reference, stage migration occurred less frequently with the Bussu classification. The widespread adoption of a single staging system, as well as the introduction of a designated topography code for cancer of the nasal vestibule, could lead to more uniformity in data reporting and improve an understanding of the incidence and disease outcome. The newly proposed carcinoma of the nasal vestibule classification by Bussu et al. has the potential to improve the staging and allocation among stages. Further analysis of survival data is needed to assess which classification system is best suited for nasal vestibule carcinoma.
据报道，鼻前庭鳞状细胞癌占所有头颈部恶性肿瘤的比例不到1%。它没有世界卫生组织国际疾病分类肿瘤学（WHO ICD-O）指定的部位编码，并且有多种系统可用于该疾病的分期，这导致了不必要的变异性以及随后数据可靠性较差。本研究的目的是评估目前可用的鼻前庭癌分期系统，包括最近由布苏（Bussu）等人引入的分类，该分类基于王（Wang）的原始概念，但解剖学界限更清晰。通过对148例患者的回顾性分析，评估了鼻前庭癌的不同分期系统（国际抗癌联盟（UICC）鼻腔分期、UICC头颈部皮肤癌分期、王分期和布苏等人的分期）。根据布苏等人的分期系统，各期患者的分配最为均衡。以王分期作为参考时，布苏分期的分期迁移较少发生。采用单一分期系统以及引入鼻前庭癌指定的部位编码，可能会使数据报告更加统一，并增进对发病率和疾病转归的了解。布苏等人新提出的鼻前庭癌分类有可能改善分期以及各期之间的分配。需要进一步分析生存数据，以评估哪种分类系统最适合鼻前庭癌。
