Centre for Social Research in Health, UNSW Sydney, Sydney, NSW, Australia.
The Kirby Institute, UNSW Sydney, Sydney, NSW, Australia.
Addiction. 2021 May;116(5):1162-1171. doi: 10.1111/add.15277. Epub 2020 Oct 18.
Hepatitis C (HCV) is a global public health concern, particularly in the prison setting where prevalence is substantially higher than in the general population. Direct-acting antivirals have changed the treatment landscape, allowing for treatment scale-up efforts potentially sufficient to achieve prevention of onward transmission (treatment-as-prevention). The Surveillance and Treatment of Prisoners with hepatitis C (SToP-C) study was the first trial to examine the efficacy of HCV treatment-as-prevention in the prison setting. Social capital is a social resource which has been found to influence health outcomes. This qualitative study sought to understand the role of social capital within an HCV treatment-as-prevention trial in the prison setting.
Semi-structured in-depth interviews were undertaken with participants recruited from the SToP-C study following HCV treatment completion (with cure).
Three male correctional centres in New South Wales, Australia (including two maximum-security and one minimum-security).
Twenty-three men in prison participated in semi-structured interviews.
Thematic analysis of transcripts was completed using a social capital framework, which enabled exploration of the ways in which bonding, bridging and linking social capital promoted or inhibited HCV treatment uptake within a treatment-as-prevention trial.
Social capital fostered HCV treatment uptake within an HCV treatment-as-prevention trial in the prison setting. Bonding social capital encouraged treatment uptake and alleviated concerns of side effects, bridging social capital supported prison-wide treatment uptake, and linking social capital fostered trust in study personnel (including nurses and correctional officers), thereby enhancing treatment engagement.
Social capital, including bonding, bridging and linking, can play an important role in hepatitis C treatment-as-prevention efforts within the male prison setting.
丙型肝炎（HCV）是一个全球性的公共卫生关注点，尤其是在监狱环境中，其患病率明显高于普通人群。直接作用抗病毒药物改变了治疗格局，使治疗规模扩大的努力有可能足以实现预防传播（治疗即预防）。监测和治疗监狱中丙型肝炎患者（SToP-C）研究是第一个在监狱环境中检验 HCV 治疗即预防疗效的试验。社会资本是一种社会资源，已发现其影响健康结果。这项定性研究旨在了解社会资本在监狱环境中的 HCV 治疗即预防试验中的作用。
在 HCV 治疗完成（治愈）后，从 SToP-C 研究中招募参与者进行半结构式深入访谈。
澳大利亚新南威尔士州的三个男子惩教中心（包括两个最高安全级别和一个最低安全级别）。
23 名在监狱中的男性参与了半结构式访谈。
使用社会资本框架对转录本进行主题分析，该框架使我们能够探索在治疗即预防试验中，结合、桥接和联系社会资本促进或抑制 HCV 治疗采用的方式。
社会资本促进了监狱中 HCV 治疗即预防试验中的 HCV 治疗采用。结合社会资本鼓励治疗采用并减轻对副作用的担忧，桥接社会资本支持监狱范围内的治疗采用，而联系社会资本则促进了对研究人员（包括护士和惩教官员）的信任，从而增强了治疗参与度。
社会资本，包括结合、桥接和联系，可以在男性监狱环境中的丙型肝炎治疗即预防工作中发挥重要作用。
