Dumler F, Vulpetti A T, Guise E R, Levin N W
Clin Nephrol. 1977 Aug;8(2):349-53.
Osteonecrosis of the femoral head results in an increased uptake of 18F due to a reparative reaction in the necrotic area and its surroundings. Twenty hemodialysis and twenty-seven post-transplant patients were studied serially. In the hemodialysis group, nine patients had positive scintigraphs and eleven had negative studies. All were asymptomatic. In the transplant group, twelve were positive and fifteen were negative. Four patients with positive scans later developed unequivocal clinical and radiographic evidence of osteonecrosis. Patients with negative scans have been asymptomatic and without radiological abnormalities. Age, sex, duration of dialysis, bone mineral densitometry, total steroid dose, duration of hospitalization after transplantation, and serum chemistries were not different in positive and negative patients. All patients on alternate-day steroids have negative scans. A positive 18F scintigraph antedates the occurrence of clinical and radiological findings of osteonecrosis.
由于坏死区域及其周围的修复反应，股骨头缺血性坏死导致18F摄取增加。对20名血液透析患者和27名移植后患者进行了连续研究。在血液透析组中，9名患者骨闪烁显像呈阳性，11名患者检查结果为阴性。所有患者均无症状。在移植组中，12名呈阳性，15名呈阴性。4名扫描呈阳性的患者后来出现了明确的股骨头缺血性坏死临床和影像学证据。扫描呈阴性的患者一直无症状且无放射学异常。阳性和阴性患者在年龄、性别、透析时间、骨密度测定、总类固醇剂量、移植后住院时间和血清化学指标方面并无差异。所有隔日服用类固醇的患者扫描结果均为阴性。18F骨闪烁显像阳性早于股骨头缺血性坏死的临床和影像学表现出现。
