Department of Surgical, Oncological and Stomatological Sciences (DICHIRONS), University of Palermo, 90127 Palermo, Italy.
Department of Surgical, Oncological and Stomatological Sciences (DICHIRONS), University of Palermo, 90127 Palermo, Italy.
Cell Stem Cell. 2020 Oct 1;27(4):501-502. doi: 10.1016/j.stem.2020.09.007.
The role of Hippo pathway in colorectal cancer (CRC) initiation and progression has been controversial. In this issue of Cell Stem Cell, Cheung et al. (2020) shed new light on a distinct function of the transcriptional co-activator YAP as a tumor suppressor and Wnt pathway inhibitor in CRC.
Hippo 通路在结直肠癌（CRC）发生和发展中的作用一直存在争议。在本期《Cell Stem Cell》中，Cheung 等人（2020 年）揭示了转录共激活因子 YAP 的一个独特功能，即作为 CRC 中的肿瘤抑制因子和 Wnt 通路抑制剂。
