Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD 20892, USA.
Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD 20892, USA.
Mol Cell. 2020 Oct 1;80(1):1-2. doi: 10.1016/j.molcel.2020.09.019.
Wang et al. (2020) show that binding of the second messenger ppGpp to inosine-guanosine kinase (Gsk) in E. coli modulates the levels of the key metabolite phosphoribosyl pyrophosphate (pRpp), decreasing purine synthesis to favor amino acid synthesis during stress adaptation.
Wang 等人（2020 年）表明，第二信使 ppGpp 与大肠杆菌中的肌苷-鸟苷激酶（Gsk）结合，调节关键代谢物 5-磷酸核糖-1-焦磷酸（pRpp）的水平，减少嘌呤合成，有利于压力适应过程中的氨基酸合成。
