警戒感应 ppGpp 如何改变细菌细胞代谢？从全基因组方法到结构再到生理学。
How Does the Alarmone ppGpp Change Bacterial Cell Metabolism? From Genome-wide Approaches to Structure to Physiology.
机构信息
Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD 20892, USA.
Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD 20892, USA.
出版信息
Mol Cell. 2020 Oct 1;80(1):1-2. doi: 10.1016/j.molcel.2020.09.019.
PMID:33007252
Abstract
Wang et al. (2020) show that binding of the second messenger ppGpp to inosine-guanosine kinase (Gsk) in E. coli modulates the levels of the key metabolite phosphoribosyl pyrophosphate (pRpp), decreasing purine synthesis to favor amino acid synthesis during stress adaptation.
摘要
Wang 等人（2020 年）表明，第二信使 ppGpp 与大肠杆菌中的肌苷-鸟苷激酶（Gsk）结合，调节关键代谢物 5-磷酸核糖-1-焦磷酸（pRpp）的水平，减少嘌呤合成，有利于压力适应过程中的氨基酸合成。
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