Department of Cardiothoracic Surgery, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Ann Thorac Surg. 2021 Jun;111(6):1998-2003. doi: 10.1016/j.athoracsur.2020.07.041. Epub 2020 Sep 29.
Bilateral internal thoracic artery (BITA) grafting is questionable in octogenarians because of shorter life expectancy and increased risk of perioperative complications. The aim of this study was to examine the safety and effectiveness of performing BITA and single internal thoracic artery (SITA) grafts in patients older than 80 years of age.
This study compared outcomes in 201 consecutive octogenarians who underwent isolated BITA grafting with those of 280 consecutive octogenarians who underwent SITA and saphenous vein grafting during 1996 to 2011. Insulin-dependent diabetes, ejection fraction <30, and emergency operations were more common among patients who underwent SITA, and the prevalence of left main coronary artery disease was lower. Propensity score matching was used to control for these differences, thus generating well-matched groups of 190 patients each.
There were no significant differences in early mortality between the unmatched groups: 3.2% in the BITA group and 8.6% in the SITA group (P = .12). Rates of sternal wound infection were also similar, 1.5% vs 1.7%, respectively. Differences were not observed in the occurrences of perioperative stroke (3.5% vs 2.5%; P = .999) and myocardial infarction (1.5% vs 3.6%; P = .166). The results were similar for the matched groups. Long-term survival between the unmatched groups and survival between the matched groups were not significantly different.
This study shows equal long-term survival for BITA and SITA grafting in octogenarians. BITA is an acceptable alternative to SITA grafting in low-risk octogenarians and in the presence of a calcified aorta or poor-quality saphenous vein graft.
由于预期寿命较短且围手术期并发症风险增加,双侧胸廓内动脉(BITA)移植在 80 岁以上的患者中受到质疑。本研究旨在研究在 80 岁以上患者中进行 BITA 和单根胸廓内动脉(SITA)移植的安全性和有效性。
本研究比较了 1996 年至 2011 年间 201 例 80 岁以上患者接受单纯 BITA 移植和 280 例接受 SITA 和隐静脉移植的患者的结果。SITA 组患者中更常见胰岛素依赖性糖尿病、射血分数<30 和急诊手术,而左主干冠状动脉疾病的患病率较低。采用倾向评分匹配来控制这些差异,从而生成了每组 190 例匹配良好的患者。
未匹配组之间的早期死亡率无显著差异:BITA 组为 3.2%,SITA 组为 8.6%(P=0.12)。胸骨伤口感染率也相似,分别为 1.5%和 1.7%。围手术期卒中(3.5%对 2.5%;P=0.999)和心肌梗死(1.5%对 3.6%;P=0.166)的发生率也没有差异。匹配组的结果也相似。未匹配组之间的长期生存率和匹配组之间的生存率没有显著差异。
本研究表明,80 岁以上患者的 BITA 和 SITA 移植具有同等的长期生存率。在低危 80 岁以上患者和主动脉钙化或隐静脉移植物质量差的情况下,BITA 是 SITA 移植的可接受替代方法。