Kubota Y, Inagaki S, Shimada S, Kito S, Zaidi M, Girgis S I, MacIntyre I, Tohyama M
Brain Res. 1987 Jul 14;415(2):385-8. doi: 10.1016/0006-8993(87)90226-5.
A plexus of calcitonin gene-related peptide (CGRP)-containing fibers were transiently found in the developing cerebellum of the rat by means of the indirect immunofluorescent method. CGRP-like immunoreactive fibers appeared in the cerebellum by embryonic day 22. Immunoreactive fibers rapidly increased and these made a dense plexus in the Purkinje cell layer by postnatal day 2. However, only a few if any immunoreactive fibers were seen in the Purkinje cell layer or molecular layer of adult rats.
通过间接免疫荧光法在大鼠发育中的小脑中短暂发现了一个含有降钙素基因相关肽(CGRP)的纤维丛。在胚胎第22天,小脑出现了CGRP样免疫反应性纤维。免疫反应性纤维迅速增加,并在出生后第2天在浦肯野细胞层形成致密的纤维丛。然而,在成年大鼠的浦肯野细胞层或分子层中,即使有也只能看到少数免疫反应性纤维。