老年非霍奇金淋巴瘤幸存者接受化疗后的生活质量及相关因素。

Quality of life in older survivors of non-Hodgkin's lymphoma who received chemotherapy and related factors.

机构信息

Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo National Hospital, Jakarta, Indonesia.; Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.

Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo National Hospital, Jakarta, Indonesia.; National Cancer Center-Dharmais Cancer Hospital, Jakarta, Indonesia..

出版信息

J Geriatr Oncol. 2021 Mar;12(2):326-331. doi: 10.1016/j.jgo.2020.09.002. Epub 2020 Sep 30.

DOI:10.1016/j.jgo.2020.09.002

PMID:33008767

Abstract

INTRODUCTION

Cancer and its treatment have a broad impact on patients' Quality of Life (QoL). Previous researches showed that many factors in Comprehensive Geriatric Assessment (CGA) affect QoL. CGA could predict toxicity, overall survival rate and can help adjust the choice and intensity of treatment in each patient. However, there has been no research explicitly exploring factors related to the QoL in older patients with Non-Hodgkin's Lymphoma (NHL). This research aims to explore the how factors in CGA relate to the QoL in older patients with NHL.

MATERIALS AND METHOD

The study design was cross-sectional in NHL patients aged ≥ 60 years, research was conducted in Integrated Geriatric Polyclinic and Hemato-Oncology Polyclinic of three public hospitals in Jakarta, during March-August 2019.

RESULTS

There were 62 subjects, with a median age of 66 years, 56.5% male. The result showed that most of the patients have a good QoL, based on each domain of SF-36 and EORTC QLQ-C30. In multivariate analysis, it was found that depression and frailty status were related to PCS SF-36 domain with PR 12.086 (95% CI 1.596-92.124) and PR 5.622 (95% CI 1.060-29.807), respectively. Multivariate analysis with SF-36's Mental Component Summary (MCS) showed a significant relationship with depression status with PR 24.400 (95% CI 2.961-140.539). While the results of multivariate analysis with the EORTC QLQ-C30 functional scale showed a significant relationship with the ECOG performance score with PR 171 (95% CI 8.470-3452.28).

DISCUSSIONS

After multivariate analysis, only frailty status, depression status and ECOG performance score have a statistically significant relationship.

摘要

简介

癌症及其治疗对患者的生活质量（QoL）有广泛影响。先前的研究表明，综合老年评估（CGA）中的许多因素会影响 QoL。CGA 可以预测毒性、总生存率，并有助于调整每位患者的治疗选择和强度。然而，目前尚无研究明确探讨与非霍奇金淋巴瘤（NHL）老年患者的 QoL 相关的因素。本研究旨在探讨 CGA 中的因素如何与 NHL 老年患者的 QoL 相关。

材料和方法

该研究设计为横断面研究，纳入年龄≥60 岁的 NHL 患者，于 2019 年 3 月至 8 月在雅加达的综合老年科和血液肿瘤科三家公立医院进行。

结果

共有 62 名受试者，中位年龄为 66 岁，男性占 56.5%。结果显示，根据 SF-36 和 EORTC QLQ-C30 的每个领域，大多数患者的 QoL 良好。多变量分析发现，抑郁和衰弱状态与 PCS SF-36 域相关，PR 值分别为 12.086（95%CI 1.596-92.124）和 5.622（95%CI 1.060-29.807）。SF-36 心理成分综合量表的多变量分析显示，与抑郁状态显著相关，PR 值为 24.400（95%CI 2.961-140.539）。而 EORTC QLQ-C30 功能量表的多变量分析显示，与 ECOG 表现评分显著相关，PR 值为 171（95%CI 8.470-3452.28）。