Vallance Jeffrey K H, Courneya Kerry S, Jones Lee W, Reiman Tony
Faculty of Physical Education, University of Alberta, E-424 Van Vliet Centre, Edmonton, Alberta, Canada.
Psychooncology. 2005 Nov;14(11):979-91. doi: 10.1002/pon.910.
The primary purpose of this study was to examine differences in quality of life (QoL) between non-Hodgkin's lymphoma (NHL) survivors meeting and not meeting public health exercise guidelines. A secondary purpose was to examine exercise behavior changes across three distinct cancer-related time periods (i.e. prediagnosis, on treatment and off treatment). Using a retrospective survey design, 438 NHL survivors residing in Alberta, Canada completed a mailed questionnaire that assessed self-reported exercise prediagnosis, on treatment and off treatment, and current QoL. Descriptive analyses indicated that 33.8, 6.5 and 23.7% of NHL survivors met public health exercise guidelines during prediagnosis, on treatment, and off treatment time periods, respectively. Multivariate analyses of variance indicated that NHL survivors meeting public health exercise guidelines during postdiagnosis time periods had higher current QoL scores than NHL survivors not meeting guidelines. QoL difference scores between the two groups met proposed standards for clinically important differences. Multivariate analyses also indicated significant differences in exercise behavior across the three cancer-related time periods (all p's<0.01). These analyses were unchanged after statistically controlling for important medical and demographic variables. The results of this study provide evidence that NHL survivors meeting public health exercise guidelines on and off treatment reported higher current QoL than those survivors not meeting guidelines. These findings corroborate research examining exercise behavior in other cancer survivor groups and provide preliminary data to support a randomized controlled trial on exercise and QoL in this population.
本研究的主要目的是检验符合和不符合公共卫生运动指南的非霍奇金淋巴瘤（NHL）幸存者在生活质量（QoL）方面的差异。次要目的是考察在三个不同的癌症相关时间段（即诊断前、治疗期间和治疗后）的运动行为变化。采用回顾性调查设计，438名居住在加拿大艾伯塔省的NHL幸存者完成了一份邮寄问卷，该问卷评估了自我报告的诊断前、治疗期间和治疗后的运动情况以及当前的生活质量。描述性分析表明，分别有33.8%、6.5%和23.7%的NHL幸存者在诊断前、治疗期间和治疗后时间段符合公共卫生运动指南。多变量方差分析表明，在诊断后时间段符合公共卫生运动指南的NHL幸存者当前生活质量得分高于不符合指南的NHL幸存者。两组之间的生活质量差异得分达到了临床重要差异的提议标准。多变量分析还表明，在三个癌症相关时间段的运动行为存在显著差异（所有p值<0.01）。在对重要的医学和人口统计学变量进行统计控制后，这些分析结果不变。本研究结果提供了证据，表明在治疗期间和治疗后符合公共卫生运动指南的NHL幸存者报告的当前生活质量高于不符合指南的幸存者。这些发现证实了对其他癌症幸存者群体运动行为的研究，并为支持针对该人群进行运动与生活质量的随机对照试验提供了初步数据。
