Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
Ophthalmology, Department of Surgery, The University of Melbourne, Melbourne, Australia.
Retina. 2021 May 1;41(5):1094-1101. doi: 10.1097/IAE.0000000000002982.
To evaluate the performance of microperimetry and low-luminance visual acuity for detecting late age-related macular degeneration (AMD) onset.
Two hundred ninety-two individuals with bilateral large drusen in the Laser Intervention in the Early Stages of AMD study underwent best-corrected visual acuity, low-luminance visual acuity, and microperimetry testing as well as multimodal imaging to detect late (neovascular or atrophic) AMD onset. The performance of the change in the measurement from baseline of each of visual function test for detecting late AMD onset was compared.
The area under the receiver operating characteristic curve for detecting neovascular and atrophic AMD onset was not significantly different for low-luminance visual acuity (area under the receiver operating characteristic curve = 0.71 and 0.56, respectively) and microperimetry (area under the receiver operating characteristic curve = 0.82 and 0.62, respectively) compared with best-corrected visual acuity (area under the receiver operating characteristic curve = 0.57 and 0.56, respectively; P ≥ 0.126 for all). There was also only a fair degree of agreement between the three visual function measures for detecting the onset of neovascular and atrophic AMD (κ ≥ 0.24).
Microperimetry, low-luminance visual acuity, and best-corrected visual acuity demonstrate limited performance for detecting the earliest onset of late AMD. It remains to be established whether they perform better than current methods designed to enable self-detection of neovascular AMD onset, such as Amsler grid testing.
评估微视野计和低亮度视力在检测晚期年龄相关性黄斑变性（AMD）发病中的性能。
在激光干预早期 AMD 研究中，292 名双侧有大量玻璃膜疣的个体接受了最佳矫正视力、低亮度视力和微视野计检查以及多模态成像，以检测晚期（新生血管或萎缩性）AMD 的发病。比较了每种视觉功能测试从基线变化的测量值在检测晚期 AMD 发病中的性能。
低亮度视力（ROC 曲线下面积分别为 0.71 和 0.56）和微视野计（ROC 曲线下面积分别为 0.82 和 0.62）检测新生血管性和萎缩性 AMD 发病的曲线下面积与最佳矫正视力（ROC 曲线下面积分别为 0.57 和 0.56）无显著差异（所有 P≥0.126）。对于检测新生血管性和萎缩性 AMD 的发病，三种视觉功能测量之间的一致性也只有中等程度（κ≥0.24）。
微视野计、低亮度视力和最佳矫正视力在检测晚期 AMD 的最早发病方面表现出有限的性能。它们是否比目前旨在实现新生血管性 AMD 发病自我检测的方法（如 Amsler 网格测试）表现更好，仍有待确定。
