School of Anatomical Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Department of Anatomy, School of Medicine, Sefako Makgatho Health Sciences University, Pretoria, South Africa.
J Comp Neurol. 2021 Jan;529(1):28-51. doi: 10.1002/cne.25046. Epub 2020 Oct 20.
The current study provides an analysis of the cytoarchitecture, myeloarchitecture, and chemoarchitecture of the amygdaloid body of the banded mongoose (Mungos mungo) and domestic ferret (Mustela putorius furo). Using architectural and immunohistochemical stains, we observe that the organization of the nuclear and cortical portions of the amygdaloid complex is very similar in both species. The one major difference is the presence of a cortex-amygdala transition zone observed in the domestic ferret that is absent in the banded mongoose. In addition, the chemoarchitecture is, for the most part, quite similar in the two species, but several variances, such as differing densities of neurons expressing the calcium-binding proteins in specific nuclei are noted. Despite this, certain aspects of the chemoarchitecture, such as the cholinergic innervation of the magnocellular division of the basal nuclear cluster and the presence of doublecortin expressing neurons in the shell division of the accessory basal nuclear cluster, appear to be consistent features of the Eutherian mammal amygdala. The domestic ferret presented with an overall lower myelin density throughout the amygdaloid body than the banded mongoose, a feature that may reflect artificial selection in the process of domestication for increased juvenile-like behavior in the adult domestic ferret, such as a muted fear response. The shared, but temporally distant, ancestry of the banded mongoose and domestic ferret allows us to generate observations relevant to understanding the relative influence that phylogenetic constraints, adaptive evolutionary plasticity, and the domestication process may play in the organization and chemoarchitecture of the amygdaloid body.
本研究对条纹獴（Mungos mungo）和雪貂（Mustela putorius furo）的扁桃体体的细胞构筑、髓鞘构筑和化学构筑进行了分析。使用构筑和免疫组织化学染色，我们观察到这两个物种的扁桃体复合体的核和皮质部分的组织非常相似。唯一的主要区别是在雪貂中存在皮质-扁桃体过渡区，而在条纹獴中则不存在。此外，两种物种的化学构筑在很大程度上非常相似，但也存在一些差异，例如在特定核中表达钙结合蛋白的神经元密度不同。尽管如此，某些化学构筑的方面，例如基底核簇的大细胞部分的胆碱能神经支配，以及辅助基底核簇的壳部分中双皮质素表达神经元的存在，似乎是真兽类哺乳动物扁桃体的一致特征。与条纹獴相比，雪貂的整个扁桃体体的髓鞘密度总体较低，这一特征可能反映了在驯化过程中为了增加成年雪貂的类似幼年的行为而进行的人工选择，例如减弱的恐惧反应。条纹獴和雪貂具有共同的、但时间上遥远的祖先，这使我们能够对理解进化过程中的种系约束、适应性进化可塑性以及驯化过程对扁桃体体的组织和化学构筑的相对影响产生相关观察。
