Glazkova D V, Urusov F A, Bogoslovskaya E V, Shipulin G A
Center for Strategic Planning and Management of Medical and Biological Health Risks, Federal Medical-Biological Agency of the Russian Federation, Moscow, 119992 Russia.
Izmerov Research Institute of Occupational Health, Moscow, 105275 Russia.
Mol Biol (Mosk). 2020 Sep-Oct;54(5):707-717. doi: 10.31857/S0026898420050031.
It is commonly known that the antiviral activity of the TRIM5α protein, the intracellular retrovirus restriction factor, underlies the resistance of the Old World monkeys to HIV-1. This fact suggests that TRIM5α can potentially be used to cure HIV-1 infection in humans. The present review considers the mechanisms of HIV-1 replication inhibition by the TRIM5a protein and the prospects for using it in gene therapy of HIV infection.
