School of Life Sciences, Chongqing University, No. 55 Daxuecheng South Rd., Shapingba, Chongqing, 401331, China.
College of Veterinary Medicine, China Agricultural University, HaiDian District, Beijing, 100094, China.
Database (Oxford). 2021 Aug 5;2020. doi: 10.1093/database/baaa070.
The recent outbreak of COVID-19 caused by a new zoonotic origin coronavirus (SARS-CoV-2 or 2019-nCoV) has sound the alarm for the potential spread of epidemic coronavirus crossing species. With the urgent needs to assist disease control and to provide invaluable scientific information, we developed the coronavirus database (CoVdb), an online genomic, proteomic and evolutionary analysis platform. CoVdb has brought together genomes of more than 5000 coronavirus strains, which were collected from 1941 to 2020, in more than 60 countries and in hosts belonging to more than 30 species, ranging from fish to human. CoVdb presents comprehensive genomic information, such as gene function, subcellular localization, topology and protein structure. To facilitate coronavirus research, CoVdb also provides flexible search approaches and online tools to view and analyze protein structure, to perform multiple alignments, to automatically build phylogenetic trees and to carry on evolutionary analyses. CoVdb can be accessed freely at http://covdb.popgenetics.net. Hopefully, it will accelerate the progress to develop medicines or vaccines to control the pandemic of COVID-19.
近期由新型人畜共患病源冠状病毒（SARS-CoV-2 或 2019-nCoV）引发的 COVID-19 疫情爆发，敲响了跨物种传播流行冠状病毒的警钟。为了协助疾病控制并提供宝贵的科学信息，我们开发了冠状病毒数据库（CoVdb），这是一个在线基因组、蛋白质组和进化分析平台。CoVdb 汇集了来自 1941 年至 2020 年，60 多个国家和 30 多种宿主（从鱼类到人类）的超过 5000 株冠状病毒株的基因组。CoVdb 提供了全面的基因组信息，如基因功能、亚细胞定位、拓扑结构和蛋白质结构。为了促进冠状病毒研究，CoVdb 还提供了灵活的搜索方法和在线工具，用于查看和分析蛋白质结构、进行多重比对、自动构建系统发育树和进行进化分析。CoVdb 可在 http://covdb.popgenetics.net 免费访问。希望它能加速开发药物或疫苗以控制 COVID-19 大流行的进程。
