Pinner John F L, Coffman Brian A, Stephen Julia M
The Mind Research Network, Albuquerque, NM, United States; Department of Psychology, The University of New Mexico, Albuquerque, NM, United States.
The Mind Research Network, Albuquerque, NM, United States; The University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Neuroscience. 2020 Nov 21;449:74-87. doi: 10.1016/j.neuroscience.2020.09.053. Epub 2020 Oct 1.
The behavioral, cognitive, and sensory difficulties experienced by individuals exposed to alcohol prenatally currently fail to provide early identification for fetal alcohol spectrum disorder (FASD). Attempting to advance this pursuit through a multivariate analysis, we collected magnetoencephalography (MEG) data during auditory, somatosensory, visual paradigms, DTI, and behavior in adolescents ages 12-21 years (FASD: N = 13; HC: N = 20). We assessed the relationship between brain function (MEG) and structure (fractional anisotropy (FA)) utilizing joint independent component analysis (jICA), and examined how this measure relates to behavior. We identified 5 components that reveal group differences in co-variation between MEG and FA. For example, component 5 (t = 3.162, p = 0.003, Hedges' g = 1.13) contained MEG activity corresponding to all three sensory modalities, most robustly in occipital lobes, and DTI-derived cerebellar FA, underlying the role of the cerebellum in sensory processing. Further, in HCs component 5's loading factor was positively correlated with verbal ability (r = 0.646, p = 0.002), indicating higher covariation was associated with better verbal performance. Interestingly, this relationship is lacking in FASD (r = 0.009, p = 0.979). Also, component 5 loading factor negatively correlated with impulsivity (r = -0.527, p = 0.002), indicating that stronger function-structure associations were associated with individuals with lower impulsivity. These findings suggest that multimodal integration of MEG and FA provides novel associations between structure and function that may help differentiate adolescents with FASD from HC.
目前，产前接触酒精的个体所经历的行为、认知和感觉困难无法为胎儿酒精谱系障碍（FASD）提供早期识别。为了通过多变量分析推进这一研究，我们收集了12至21岁青少年在听觉、体感、视觉范式、弥散张量成像（DTI）和行为过程中的脑磁图（MEG）数据（FASD组：N = 13；健康对照组：N = 20）。我们利用联合独立成分分析（jICA）评估脑功能（MEG）与结构（分数各向异性（FA））之间的关系，并研究这种测量方法与行为的关系。我们识别出5个成分，这些成分揭示了MEG和FA之间协变的组间差异。例如，成分5（t = 3.162，p = 0.003，Hedges' g = 1.13）包含与所有三种感觉模态相对应的MEG活动，在枕叶最为显著，以及DTI衍生的小脑FA，这表明小脑在感觉处理中的作用。此外，在健康对照组中，成分5的负荷因子与语言能力呈正相关（r = 0.646，p = 0.002），表明更高的协变与更好的语言表现相关。有趣的是，FASD组不存在这种关系（r = 0.009，p = 0.979）。而且，成分5负荷因子与冲动性呈负相关（r = -0.527，p = 0.002），表明更强的功能 - 结构关联与冲动性较低的个体相关。这些发现表明，MEG和FA的多模态整合提供了结构与功能之间的新关联，这可能有助于将患有FASD的青少年与健康对照组区分开来。
