Pålsson J, Ricksten S E, Lundin S
Circ Shock. 1987;22(1):65-72.
This study describes the hemodynamic, metabolic, and respiratory effects of a 4-h continuous intravenous infusion of live Escherichia coli bacteria (10(9)/h) in conscious, unrestrained rats. The early response to bacterial infusion was moderate hypotension and a marked and sustained increase in heart rate and respiratory rate. During later stages of bacteria infusion a marked decrease in stroke volume and cardiac output was observed, while total peripheral resistance increased. Arterial blood gas measurements showed an early primary respiratory alkalosis, while later stages of bacteria infusion were accompanied by progressive development of metabolic acidosis. This small-sized animal shock model may be useful for further studies, particularly since conscious rats were used to avoid the influence of anesthesia upon the development of septic shock.
本研究描述了在清醒、不受束缚的大鼠中连续4小时静脉输注活大肠杆菌（10⁹/小时）对血流动力学、代谢和呼吸的影响。细菌输注的早期反应是中度低血压以及心率和呼吸频率显著且持续增加。在细菌输注的后期，观察到每搏输出量和心输出量显著下降，而总外周阻力增加。动脉血气测量显示早期为原发性呼吸性碱中毒，而细菌输注后期伴有代谢性酸中毒的逐渐发展。这种小型动物休克模型可能对进一步研究有用，特别是因为使用清醒大鼠避免了麻醉对脓毒症休克发展的影响。
