Pålsson J, Ricksten S E, Delle M, Lundin S
Department of Anesthesia and Intensive Care, Sahlgren's Hospital, Göteborg, Sweden.
Circ Shock. 1988 Feb;24(2):133-41.
Changes in postganglionic renal sympathetic nerve activity, arterial pressure, and heart rate were measured in conscious rats during intravenous infusion of live E. coli bacteria (10(9)/h) or bolus injection of E. coli endotoxin (20 mg/kg). Bacteria infusion was associated with a marked and parallel increase in heart rate and sympathetic activity with only minor changes in mean arterial pressure. The early response to bolus injection of endotoxin was a short-lasting decrease in mean arterial pressure combined with a marked increase in sympathetic activity and heart rate, probably due to baroreceptor unloading. However, when mean arterial pressure returned to pre-endotoxin levels, sympathetic activity and heart rate remained markedly elevated, indicating a partly nonreflexogenic increase in central sympathetic outflow. This study using direct nerve recordings of sympathetic activity in conscious animals confirms earlier clinical observations of an increased activity of the sympathetic nervous system in septic shock.
在清醒大鼠静脉输注活大肠杆菌（10⁹/小时）或推注大肠杆菌内毒素（20毫克/千克）期间，测量节后肾交感神经活动、动脉血压和心率的变化。输注细菌与心率和交感神经活动显著平行增加相关，而平均动脉压仅有轻微变化。推注内毒素的早期反应是平均动脉压短暂下降，同时交感神经活动和心率显著增加，这可能是由于压力感受器卸载所致。然而，当平均动脉压恢复到内毒素注射前水平时，交感神经活动和心率仍显著升高，表明中枢交感神经传出有部分非反射性增加。这项在清醒动物中直接记录交感神经活动的研究证实了早期关于感染性休克中交感神经系统活动增加的临床观察结果。
