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Forensic Sci Int. 2020 Dec;317:110516. doi: 10.1016/j.forsciint.2020.110516. Epub 2020 Sep 17.
Hydroxycocaines in hair were investigated with many hundreds of head and body hair samples. All samples were washed by a published extensive aqueous method prior to confirmation by LC-MS/MS. Concentrations, percent of cocaine, and ratios of para- and meta-hydroxycocaines to ortho-hydroxycocaine are presented. Hydroxycocaines as percent of cocaine did not appear to be affected by cocaine concentrations, but were shown to increase with cocaethylene concentrations. Stability of hydroxycocaines over a year of ambient storage was demonstrated. Ortho-hydroxycocaine was shown to be formed by exposure of cocaine-positive hair to peroxide, while para- and meta-hydroxycocaines were not. Presence of para- or meta-hydroxycocaine at > 0.05% of cocaine is proposed as indicating ingestion of cocaine. This indicator prevents black hair from being more likely interpreted as positive for ingestion than lighter colored hair.
对数百个头和身体毛发样本中的羟基可卡因而进行了研究。所有样本均通过已发表的广泛水提取方法进行了清洗，然后通过 LC-MS/MS 进行了确认。结果给出了浓度、可卡因比例以及对-和间-羟基可卡因为邻-羟基可卡因为的比值。羟基可卡因占可卡因的比例似乎不受可卡因浓度的影响，但随着可乐因浓度的增加而增加。证明了在一年的环境储存中羟基可卡因的稳定性。研究表明，将含有可卡因的毛发暴露于过氧化物中会形成邻-羟基可卡因，而对-和间-羟基可卡因则不会。如果存在对-或间-羟基可卡因超过可卡因的 0.05%，则可以表明摄入了可卡因。这个指标可以防止因黑色头发比浅色头发更有可能被误判为摄入可卡因而产生的偏见。
