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动态压缩和剪切下猪和人脂肪组织加载反应的比较:一项初步研究。

Comparison of porcine and human adipose tissue loading responses under dynamic compression and shear: A pilot study.

作者信息

Sun Zhaonan, Lee Sang-Hyun, Gepner Bronislaw D, Rigby Joshua, Hallman Jason J, Kerrigan Jason R

机构信息

Center for Applied Biomechanics, University of Virginia, Charlottesville, VA, 22911, USA.

Center for Applied Biomechanics, University of Virginia, Charlottesville, VA, 22911, USA.

出版信息

J Mech Behav Biomed Mater. 2021 Jan;113:104112. doi: 10.1016/j.jmbbm.2020.104112. Epub 2020 Sep 28.

DOI:10.1016/j.jmbbm.2020.104112
PMID:33010697
Abstract

Understanding the mechanical properties of human adipose tissue, and its influence on seat belt-pelvis interaction is beneficial for computational human body models that are developed for injury prediction in the vehicle crashworthiness simulations. While various studies have characterized adipose tissue, most of the studies used porcine adipose tissue as a surrogate, and none of the studies were performed at loading rates relevant for motor vehicle collisions. In this work, the mechanical response of human and porcine adipose tissue was studied. Two dynamic loading modes (compression and simple shear) were tested in adipose tissue extracted from the human abdomen and porcine back. An Ogden hyperelastic model was used to fit the loading response, and specific material parameters were obtained for each specimen. Two-sample t-tests were performed to compare the effective shear moduli and peak stresses from porcine and human samples. The material response of the human adipose tissue was consistent with previous studies. Porcine adipose tissue was found to be significantly stiffer than human adipose tissue under compression and shear loading. Also, when material model parameters were fit to only one loading mode, the predicted response in the other mode showed a poor fit.

摘要

了解人体脂肪组织的力学特性及其对安全带与骨盆相互作用的影响,对于在车辆碰撞安全性模拟中用于损伤预测而开发的计算人体模型是有益的。虽然各种研究已经对脂肪组织进行了表征,但大多数研究使用猪脂肪组织作为替代物,并且没有一项研究是在与机动车碰撞相关的加载速率下进行的。在这项工作中,研究了人体和猪脂肪组织的力学响应。在从人体腹部和猪背部提取的脂肪组织中测试了两种动态加载模式(压缩和简单剪切)。使用Ogden超弹性模型来拟合加载响应,并为每个样本获得特定的材料参数。进行双样本t检验以比较猪和人类样本的有效剪切模量和峰值应力。人体脂肪组织的材料响应与先前的研究一致。发现在压缩和剪切加载下,猪脂肪组织比人体脂肪组织明显更硬。此外,当材料模型参数仅拟合一种加载模式时,在另一种模式下的预测响应显示拟合效果较差。

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