State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; Innovation Academy for Stem Cell and Regeneration, Chinese Academy of Sciences, 100101 Beijing, China; University of Chinese Academy of Sciences, Beijing 100049, China.
State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; School of Life Sciences, University of Science and Technology of China, Hefei 230000, China.
Trends Cell Biol. 2020 Nov;30(11):869-880. doi: 10.1016/j.tcb.2020.09.003. Epub 2020 Sep 30.
During embryonic brain development, neurogenesis requires the orchestration of gene expression to regulate neural stem cell (NSC) fate specification. Epigenetic regulation with specific emphasis on the modes of histone variants and histone post-translational modifications are involved in interactive gene regulation of central nervous system (CNS) development. Here, we provide a broad overview of the regulatory system of histone variants and histone modifications that have been linked to neurogenesis and diseases. We also review the crosstalk between different histone modifications and discuss how the 3D genome affects cell fate dynamics during brain development. Understanding the mechanisms of epigenetic regulation in neurogenesis has shifted the paradigm from single gene regulation to synergistic interactions to ensure healthy embryonic neurogenesis.
在胚胎大脑发育过程中，神经发生需要基因表达的协调，以调节神经干细胞（NSC）命运的特化。表观遗传调控，特别是组蛋白变体和组蛋白翻译后修饰的模式，参与了中枢神经系统（CNS）发育的基因互作调控。在这里，我们提供了一个广泛的组蛋白变体和组蛋白修饰的调控系统的概述，这些修饰与神经发生和疾病有关。我们还回顾了不同组蛋白修饰之间的串扰，并讨论了 3D 基因组如何影响大脑发育过程中的细胞命运动态。理解神经发生中表观遗传调控的机制已经将范式从单一基因调控转变为协同作用，以确保健康的胚胎神经发生。
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