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Could a Small Population of Epithelial Cells Get "Tuft" With Crohn's Disease?

作者信息

Rosen Michael J

机构信息

Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center and, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.

出版信息

Gastroenterology. 2020 Dec;159(6):2025-2027. doi: 10.1053/j.gastro.2020.09.037. Epub 2020 Oct 1.

DOI:10.1053/j.gastro.2020.09.037
PMID:33011174
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8015681/
Abstract
摘要

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Herbs-partitioned moxibustion alleviates aberrant intestinal epithelial cell apoptosis by upregulating A20 expression in a mouse model of Crohn's disease.隔药灸通过上调克罗恩病模型小鼠 A20 表达缓解异常肠上皮细胞凋亡。
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3
Intestinal epithelial barrier dysfunction in Crohn's disease.克罗恩病中的肠道上皮屏障功能障碍
Proc Soc Exp Biol Med. 1997 Apr;214(4):318-27. doi: 10.3181/00379727-214-44099.
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Rectal biopsy in patients with Crohn's disease. Normal mucosa on sigmoidoscopic examination.克罗恩病患者的直肠活检。乙状结肠镜检查显示黏膜正常。
JAMA. 1977 Jun 20;237(25):2742-4.
5
Gastrointestinal sarcoidosis resembling Crohn's disease.类似克罗恩病的胃肠道结节病
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Gene expression of group II phospholipase A2 in intestine in Crohn's disease.克罗恩病患者肠道中II型磷脂酶A2的基因表达
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Intestinal mucosa diamine oxidase activity reflects intestinal involvement in Crohn's disease.肠黏膜二胺氧化酶活性反映克罗恩病中的肠道受累情况。
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引用本文的文献

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Exogenous TSG-6 treatment alleviates DSS-induced colitis in mice by modulating Pou2f3 and promoting tuft cells differentiation.外源性TSG-6治疗通过调节Pou2f3和促进簇状细胞分化减轻DSS诱导的小鼠结肠炎。
Mol Med. 2025 Apr 29;31(1):157. doi: 10.1186/s10020-025-01230-5.
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MicroRNA-195 regulates Tuft cell function in the intestinal epithelium by altering translation of DCLK1.微小RNA-195通过改变双皮质素样激酶1(DCLK1)的翻译来调节肠上皮中的簇状细胞功能。
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本文引用的文献

1
Tuft-Cell-Derived Leukotrienes Drive Rapid Anti-helminth Immunity in the Small Intestine but Are Dispensable for Anti-protist Immunity.簇细胞衍生的白三烯在小肠中迅速引发抗寄生虫免疫,但对抗原生动物免疫不是必需的。
Immunity. 2020 Mar 17;52(3):528-541.e7. doi: 10.1016/j.immuni.2020.02.005. Epub 2020 Mar 10.
2
Regulation of immune responses by tuft cells.被毛细胞调节免疫反应。
Nat Rev Immunol. 2019 Sep;19(9):584-593. doi: 10.1038/s41577-019-0176-x.
3
Sox4 Promotes Atoh1-Independent Intestinal Secretory Differentiation Toward Tuft and Enteroendocrine Fates.Sox4 促进 Atoh1 非依赖性肠分泌细胞向微绒毛细胞和肠内分泌细胞命运分化。
Gastroenterology. 2018 Nov;155(5):1508-1523.e10. doi: 10.1053/j.gastro.2018.07.023. Epub 2018 Jul 25.
4
Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit.肠簇细胞通过检测琥珀酸触发 2 型先天免疫回路。
Immunity. 2018 Jul 17;49(1):33-41.e7. doi: 10.1016/j.immuni.2018.06.016.
5
A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling.代谢物触发簇细胞-ILC2 回路驱动小肠重塑。
Cell. 2018 Jul 12;174(2):271-284.e14. doi: 10.1016/j.cell.2018.05.014. Epub 2018 Jun 7.
6
Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine.肠簇细胞表达的 Sucnr1 的激活触发小鼠小肠中的 2 型免疫。
Proc Natl Acad Sci U S A. 2018 May 22;115(21):5552-5557. doi: 10.1073/pnas.1720758115. Epub 2018 May 7.
7
Unsupervised Trajectory Analysis of Single-Cell RNA-Seq and Imaging Data Reveals Alternative Tuft Cell Origins in the Gut.无监督轨迹分析单细胞 RNA-Seq 和成像数据揭示肠道中替代微绒毛细胞的起源。
Cell Syst. 2018 Jan 24;6(1):37-51.e9. doi: 10.1016/j.cels.2017.10.012. Epub 2017 Nov 15.
8
A single-cell survey of the small intestinal epithelium.小肠上皮的单细胞调查。
Nature. 2017 Nov 16;551(7680):333-339. doi: 10.1038/nature24489. Epub 2017 Nov 8.
9
Helminth Regulation of Immunity: A Three-pronged Approach to Treat Colitis.蠕虫对免疫的调节:治疗结肠炎的三管齐下方法。
Inflamm Bowel Dis. 2016 Oct;22(10):2499-512. doi: 10.1097/MIB.0000000000000889.
10
Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut.簇状细胞,即味觉化学感应细胞,在肠道中协调2型寄生虫免疫反应。
Science. 2016 Mar 18;351(6279):1329-33. doi: 10.1126/science.aaf1648. Epub 2016 Feb 4.