铜(II)氧化物纳米粒子与单壁碳纳米管之间的异质结形成以增强抗菌性能。

Heterojunction formation between copper(II) oxide nanoparticles and single-walled carbon nanotubes to enhance antibacterial performance.

机构信息

Department of Chemistry, Research Institute of Physics and Chemistry, Jeonbuk National University, Jeonju 54896, South Korea; Department of Chemistry, Amrit Campus, Tribhuvan University, Kathmandu 44618, Nepal.

Department of Biomedical Sciences and Institute for Medical Science, Jeonbuk National University, Jeonju 54907, South Korea.

出版信息

Int J Pharm. 2020 Nov 30;590:119937. doi: 10.1016/j.ijpharm.2020.119937. Epub 2020 Oct 1.

DOI:10.1016/j.ijpharm.2020.119937

PMID:33011252

Abstract

We delineate the excellent bactericidal efficacy of stable heterojunction nanocomposites composed of single-walled carbon nanotubes (SWCNTs) and copper(II) oxide (CuO) synthesized via facile recrystallization and calcination. The bactericidal effectiveness of the fabricated nanocomposites was examined using the standard broth-dilution method and the growth-inhibition-zone analysis method, in which bacteria cultured in an incubator in tryptic soy broth medium were subjected to the prepared samples. The bactericidal activity of all of the as-synthesized samples is evident in both methods, displaying a substantial decrease in bacterial colonies and resulting in clear inhibition zones, respectively. Among the CuO-SWCNT nanocomposites, the sample subjected to calcination at 500 °C for 5 h was found to exhibit the best performance against Staphylococcus aureus and Escherichia coli, forming inhibition zones 182% and 162% larger than those formed by pure CuO, respectively.

摘要

我们描述了由单壁碳纳米管（SWCNTs）和氧化铜（CuO）组成的稳定异质结纳米复合材料的优异杀菌效果，该复合材料通过简便的再结晶和煅烧合成。通过标准肉汤稀释法和抑菌圈分析方法来检查所制备的纳米复合材料的杀菌效果，将在胰蛋白酶大豆肉汤培养基中在孵育箱中培养的细菌暴露于制备的样品中。在这两种方法中，所有合成样品的杀菌活性都很明显，细菌菌落大量减少，分别形成清晰的抑菌圈。在 CuO-SWCNT 纳米复合材料中，在 500°C 下煅烧 5 小时的样品对金黄色葡萄球菌和大肠杆菌表现出最佳的抑制效果，形成的抑菌圈分别比纯 CuO 形成的抑菌圈大 182%和 162%。