银屑病与结直肠癌的关联。

Association of psoriasis with colorectal cancer.

作者信息

Fu Yun, Lee Cheng-Han, Chi Ching-Chi

机构信息

Department of Dermatology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.

出版信息

J Am Acad Dermatol. 2021 Dec;85(6):1429-1436. doi: 10.1016/j.jaad.2020.09.050. Epub 2020 Oct 1.

DOI:10.1016/j.jaad.2020.09.050

PMID:33011316

Abstract

BACKGROUND

The relation between psoriasis and colorectal cancer (CRC) was largely unclear.

OBJECTIVE

To investigate the association of psoriasis with CRC.

METHODS

A systematic review and meta-analysis of observational studies that examined the association of psoriasis with CRC was performed. We searched MEDLINE and Embase on March 24, 2020, for relevant studies. The Newcastle-Ottawa scale was used to evaluate the risk of bias of included studies. We conducted a random-effects model meta-analysis and subgroup analysis according to sex.

RESULTS

We included 9 cohort studies with 10,544,609 individuals. We found a significantly increased risk for CRC in patients with psoriasis (hazard ratio [HR], 1.16; 95% confidence interval [CI], 1.08-1.24). Subgroups analysis according to sex found significantly increased risk for CRC in female patients with psoriasis (HR, 1.41; 95% CI, 1.16-1.72) but not in male patients (HR, 1.18; 95% CI, 0.92-1.50).

LIMITATIONS

No data on psoriatic arthritis.

CONCLUSIONS

Patients with psoriasis have an increased risk for CRC. Gastroenterology consultation and colonoscopic examination are indicated for patients with psoriasis presenting with bowel symptoms.

摘要

背景

银屑病与结直肠癌（CRC）之间的关系在很大程度上尚不清楚。

目的

研究银屑病与CRC之间的关联。

方法

对研究银屑病与CRC关联的观察性研究进行系统评价和荟萃分析。我们于2020年3月24日在MEDLINE和Embase上检索相关研究。采用纽卡斯尔-渥太华量表评估纳入研究的偏倚风险。我们根据性别进行了随机效应模型荟萃分析和亚组分析。

结果

我们纳入了9项队列研究，共10,544,609人。我们发现银屑病患者患CRC的风险显著增加（风险比[HR]，1.16；95%置信区间[CI]，1.08 - 1.24）。按性别进行的亚组分析发现，女性银屑病患者患CRC的风险显著增加（HR，1.41；95%CI，1.16 - 1.72），而男性患者则未增加（HR，1.18；95%CI，0.92 - 1.50）。