Faculty of Medicine, Department of Pediatrics, University of Yamanashi, Yamanashi, Japan.
Faculty of Medicine, Department of Pediatrics, University of Yamanashi, Yamanashi, Japan.
Pediatr Neurol. 2020 Dec;113:43-45. doi: 10.1016/j.pediatrneurol.2020.08.021. Epub 2020 Sep 2.
Clinically mild encephalopathy with a reversible splenial lesion (MERS) is the second commonest cause of encephalopathy. Several pathogens have been detected in patients with MERS type 2, such as influenza A and B, but little is known about the proportion of cases of MERS type 2 with this pathogenesis. Human herpesvirus 6 (HHV6) is the second commonest pathogen causing acute encephalopathy. However, HHV6 has not been previously reported in patients with MERS type 2.
In this report, we describe a five-year-old boy with MERS type 2 caused by HHV6 infection. The present case was diagnosed with MERS type 2 caused by HHV6 infection based on the characteristic clinical course, the results of the virus testing, and imaging findings.
This is the first description of MERS type 2 caused by HHV6 infection. Although there is a report of MERS type 1 caused by HHV6 infection, there are no detailed reports in the literature about MERS type 2 associated with HHV6 infection. Thus the clinical findings associated with MERS type 2 caused by HHV6 infection are poorly understood. This report indicates that HHV6 can cause MERS type 2.
伴有可逆性胼胝体压部病变的临床轻度脑病（MERS）是第二种最常见的脑病病因。在 MERS 2 型患者中已经检测到了几种病原体，如甲型和乙型流感，但对于这种发病机制的 MERS 2 型病例的比例知之甚少。人类疱疹病毒 6（HHV6）是引起急性脑病的第二常见病原体。然而，以前尚未在 MERS 2 型患者中报告过 HHV6。
在本报告中，我们描述了一例由 HHV6 感染引起的 MERS 2 型五岁男孩。根据特征性临床病程、病毒检测结果和影像学发现，本病例被诊断为 HHV6 感染引起的 MERS 2 型。
这是首例由 HHV6 感染引起的 MERS 2 型病例描述。虽然有报道称 MERS 1 型由 HHV6 感染引起，但文献中没有关于与 HHV6 感染相关的 MERS 2 型的详细报告。因此，对于由 HHV6 感染引起的 MERS 2 型的临床发现了解甚少。本报告表明 HHV6 可引起 MERS 2 型。
