Agentes Microbiológicos asociados a la Reproducción Animal (ProVaginBio), Veterinary Faculty, Universidad Cardenal Herrera-CEU, CEU Universities, Valencia, Spain.
School of Veterinary Medicine and Science, University of Nottingham, Nottingham, UK.
Transbound Emerg Dis. 2021 Jul;68(4):1814-1823. doi: 10.1111/tbed.13866. Epub 2020 Oct 15.
There is some evidence that West Nile virus (WNV), which causes encephalomyelitis in equids, is an emerging disease in Europe. The aim of this study was to perform a systematic review and meta-analysis to analyse seroprevalence studies of WNV in equids in European countries between 2001 and 2018. Two electronic databases, PubMed and Scopus, were searched for relevant publications published from 2001 to 2018 using predetermined keywords. A total of 1,484 papers were initially found. After applying the eligibility criteria, 39 papers were finally included in the systematic review. Analysis of 28,089 equids from 16 European countries revealed a pooled seroprevalence of 8% (95% CI 5%-12%, p < .001, I = 99.3%) in Europe. The pooled seroprevalence was slightly higher in Mediterranean basin countries than other countries and when calculated for samples collected between 2001 and 2009 compared to 2010 to 2018. Differences in study design (e.g. sampling associated with recent outbreaks of WNV) contributed to a high degree of variability among studies. Further studies with harmonized study design and reporting of the results are recommended to better estimate and monitor European seroprevalence of WNV in equids.
有证据表明，引起马脑炎的西尼罗河病毒（WNV）在欧洲是一种新出现的疾病。本研究旨在对 2001 年至 2018 年间欧洲国家对马属动物进行的西尼罗河病毒血清学研究进行系统评价和荟萃分析。使用预定的关键词，在两个电子数据库 PubMed 和 Scopus 中搜索了 2001 年至 2018 年发表的相关出版物。最初共发现 1484 篇论文。在应用合格标准后，最终有 39 篇论文被纳入系统评价。对来自 16 个欧洲国家的 28089 匹马属动物进行分析，结果显示欧洲的总血清阳性率为 8%（95%CI 5%-12%，p<0.001，I = 99.3%）。在地中海盆地国家的血清阳性率略高于其他国家，且在 2001 年至 2009 年采集的样本与 2010 年至 2018 年采集的样本进行计算时也略高。研究设计的差异（例如，与西尼罗河病毒最近爆发相关的采样）导致了研究之间的高度变异性。建议开展进一步的研究，采用协调一致的研究设计和报告结果，以更好地估计和监测欧洲马属动物的西尼罗河病毒血清阳性率。
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