Liu Jianxin, Chen Qing, Alkam Erpan, Zheng Xiaolan, Li Yifei, Wang Lufei, Fang Jie
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University , Chengdu, Sichuan, China.
West China Medical School, Sichuan University , Chengdu, Sichuan, China.
Expert Rev Clin Immunol. 2020 Sep;16(9):943-954. doi: 10.1080/1744666X.2020.1816826. Epub 2020 Oct 6.
This meta-analysis was performed to investigate the associations between single-nucleotide polymorphisms (SNPs) in the TGF- β and Smad3 genes and arthritis.
A meta-analysis was performed in STATA 14.0, with publication bias and meta-regression analysis. All types of arthritis were included, and subgroup analyses were performed to interpret variations among different types of arthritis.
Twenty-two qualified studieswere selected to analyze the pooled accuracy, and 4 SNP sites were involved. The analysis of the TGFB1 SNP rs1800470 showed an association with arthritis in allelic (P = 0.011), homozygous (P = 0.034) and recessive (P = 0.021) genetic models. The analysis of the TGFB1 SNP rs1800471 demonstrated a close association with rheumatoid arthritis (RA) in homozygous (P = 0.000, 95%) and recessive (P = 0.008) models. The analysis of the SMAD3 SNP rs12901499 revealed a close association with osteoarthritis (OA) in the allelic (P = 0.001) model.
This research showed that genetic variants of the TGF-β pathway impact arthritis. The polymorphisms rs1800470, rs1800471 and rs12901499 were correlated with a higher prevalence of arthritis.
进行这项荟萃分析以研究转化生长因子-β（TGF-β）和Smad3基因中的单核苷酸多态性（SNP）与关节炎之间的关联。
在STATA 14.0中进行荟萃分析，并进行发表偏倚和荟萃回归分析。纳入了所有类型的关节炎，并进行亚组分析以解释不同类型关节炎之间的差异。
选择了22项合格研究来分析合并准确性，涉及4个SNP位点。对TGFB1 SNP rs1800470的分析显示，在等位基因（P = 0.011）、纯合子（P = 0.034）和隐性（P = 0.021）遗传模型中与关节炎相关。对TGFB1 SNP rs1800471的分析表明，在纯合子（P = 0.000，95%）和隐性（P = 0.008）模型中与类风湿关节炎（RA）密切相关。对SMAD3 SNP rs12901499的分析显示，在等位基因（P = 0.001）模型中与骨关节炎（OA）密切相关。
本研究表明TGF-β通路的基因变异会影响关节炎。多态性rs1800470、rs1800471和rs12901499与关节炎的较高患病率相关。
