Division of Thoracic Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
Division of Thoracic Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
Thorac Surg Clin. 2020 Nov;30(4):383-393. doi: 10.1016/j.thorsurg.2020.08.005. Epub 2020 Sep 12.
Malignant pleural mesothelioma (MPM) is a rare, aggressive malignancy of the pleural lining associated with asbestos exposure in greater than 80% of cases. It is characterized by molecular heterogeneity both between patients and within individual tumors. Next-generation sequencing technology and novel computational techniques have resulted in a greater understanding of the epigenetic, genetic, and transcriptomic hallmarks of MPM. This article reviews these features and discusses the implications of advances in MPM molecular biology in clinical practice.
恶性胸膜间皮瘤（MPM）是一种罕见的、侵袭性的胸膜衬里恶性肿瘤，与 80%以上病例中的石棉暴露有关。它的特点是患者之间和单个肿瘤内的分子异质性。下一代测序技术和新型计算技术使人们对 MPM 的表观遗传、遗传和转录组特征有了更深入的了解。本文综述了这些特征，并讨论了 MPM 分子生物学进展在临床实践中的意义。
