Department of Gastroenterology, London North West University Healthcare NHS Trust, London, UK
School of Public Health, Imperial College London, London, UK.
BMJ Case Rep. 2020 Oct 4;13(10):e234513. doi: 10.1136/bcr-2020-234513.
An 18-year-old man presented with fever, night sweats and progressive weight loss over 2 months. He had a history of Peutz-Jeghers syndrome (PJS) complicated by previous intussusception requiring left hemicolectomy. Colonoscopy revealed deep punched out ulceration throughout the colon with multiple polyps. He was investigated for tuberculosis based on his occupation as dairy farmer. Following a negative QuantiFERON test, he was started on infliximab as emergency therapy and made a good recovery at 6 months follow-up. We describe a case of newly diagnosed Crohn's disease (CD) in an adolescent with a background diagnosis of PJS. While inflammatory bowel disease, such as CD, is common in the UK, the association with PJS is very rare, with only two existing case reports in the literature.
一位 18 岁男性因发热、盗汗和进行性体重减轻 2 个月就诊。他患有 Peutz-Jeghers 综合征（PJS），曾因肠套叠而接受左半结肠切除术。结肠镜检查显示全结肠有深而穿孔的溃疡，并伴有多个息肉。由于他的职业是奶农，因此对结核病进行了检查。在 QuantiFERON 检测阴性后，他开始使用英夫利昔单抗进行紧急治疗，在 6 个月的随访中恢复良好。我们描述了一例青少年 PJS 背景下新诊断的克罗恩病（CD）病例。虽然炎症性肠病，如 CD，在英国很常见，但与 PJS 的关联非常罕见，文献中仅有两例现有病例报告。
